PRKG1 and VASP

Number of citations of the paper that reports this interaction (PMID 8182057)
91

Data Source:
HPRD (in vitro, in vivo)

		PRKG1	VASP
Gene Name		protein kinase, cGMP-dependent, type I	vasodilator-stimulated phosphoprotein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Vesicular Exosome
	Molecular Function	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly T Cell Receptor Signaling Pathway Protein Homotetramerization
Pathways		Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling	Cell junction organization TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Cell-extracellular matrix interactions Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 21907864) Obesity-related traits ( 23251661)
Protein-Protein Interactions		34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646	36 interactors: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP DMRTB1 DNMBP ERMAP FAT1 FGFR1OP FYB GSN LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX
Entrez ID		5592	7408
HPRD ID		08910	03415
Ensembl ID		ENSG00000185532	ENSG00000125753
Uniprot IDs		Q13976	P50552
PDB IDs		1ZXA 3NMD 3OCP 3OD0 3OGJ	1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?		Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle	Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Actin Filament Organization Movement Of Cell Or Subcellular Component Response To Wounding Organelle Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization Or Depolymerization Blood Coagulation Positive Regulation Of Actin Nucleation Wound Healing Hemostasis Platelet Activation Positive Regulation Of Cytoskeleton Organization Anatomical Structure Morphogenesis Regulation Of Actin Cytoskeleton Organization Cell Development Locomotion Negative Regulation Of Protein Complex Assembly Regulation Of Body Fluid Levels Regulation Of Actin Filament-based Process Negative Regulation Of Actin Filament Polymerization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cell Projection Organization Regulation Of Actin Nucleation Regulation Of Cytoskeleton Organization Negative Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Cellular Process Positive Regulation Of ATPase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Neuron Projection Development Actomyosin Structure Organization Cell Projection Morphogenesis Positive Regulation Of Organelle Organization Cell Part Morphogenesis Regulation Of ATPase Activity Positive Regulation Of Immune System Process Regulation Of Organelle Organization Anatomical Structure Development Fc Receptor Signaling Pathway Cell Activation Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Development Regulation Of Immune System Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Biogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling	abm acta cardinal colocalize concentrates concentrating factories fppppx gppppp immunolocalization listeria microinjection motile motility perinuclear phosphoprotein profilin rear redistributed rocket shigella tails underscore vaccinia vasodilator vinculin virions xppppp zyxin
Tagcloud (Difference) ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling	abm acta cardinal colocalize concentrates concentrating factories fppppx gppppp immunolocalization listeria microinjection motile motility perinuclear phosphoprotein profilin rear redistributed rocket shigella tails underscore vaccinia vasodilator vinculin virions xppppp zyxin
Tagcloud (Intersection) ?