PRKG1 and IRAG1

Number of citations of the paper that reports this interaction (PubMedID 11309393)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		PRKG1	IRAG1
Description		protein kinase cGMP-dependent 1	inositol 1,4,5-triphosphate receptor associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Sarcolemma	Cytoplasm Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase P38 Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Neuron Migration Protein Phosphorylation Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Spermatid Development Heart Development Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Glutamate Secretion Negative Regulation Of Smooth Muscle Cell Migration Dendrite Development CGMP-mediated Signaling Cerebellum Development Actin Cytoskeleton Organization Forebrain Development Vasodilation Positive Regulation Of Circadian Rhythm Regulation Of GTPase Activity Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Contraction Collateral Sprouting Relaxation Of Vascular Associated Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Platelet Aggregation Bone Growth Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Testosterone Biosynthetic Process	CGMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Relaxation Of Vascular Associated Smooth Muscle
Pathways		Ca2+ pathway	cGMP effects
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 34101054) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophilic esophagitis ( 34506852) Gait rhythm ( 26219847) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol levels in HIV infection ( 33109212) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure ( 32902719) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		40 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP VHL WDR77 ZNF646	2 interacting genes: ITPR1 PRKG1
Entrez ID		5592	10335
HPRD ID		08910	05242
Ensembl ID		ENSG00000185532	ENSG00000072952
Uniprot IDs		B1ALS0 Q13976	Q9Y6F6
PDB IDs		1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T 7LV3 7MBJ 7SSB 7T4T 7T4U 7T4V 7T4W
Enriched GO Terms of Interacting Partners?		Response To Ketone Positive Regulation Of Hormone Secretion Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Enzyme Binding Regulation Of System Process CGMP-mediated Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Relaxation Of Vascular Associated Smooth Muscle Positive Regulation Of Secretion Cellular Response To Testosterone Stimulus Relaxation Of Smooth Muscle Intracellular Signaling Cassette Epithelial Cell Differentiation Involved In Prostate Gland Development Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Response To Phorbol 13-acetate 12-myristate Response To Alcohol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anatomical Structure Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Hormone Secretion Response To Purine-containing Compound Epithelial Fluid Transport Regulation Of Smooth Muscle Cell Proliferation Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Protein Homotetramerization Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Negative Regulation Of Sequestering Of Calcium Ion Inositol 1,4,5 Trisphosphate Binding Z Disc Positive Regulation Of Bone Resorption Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Forskolin Sarcoplasmic Reticulum A Band Monoatomic Ion Channel Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Secretion By Cell Regulation Of Cardiac Muscle Hypertrophy Response To Forskolin Regulation Of Muscle Contraction Regulation Of Developmental Process CGMP Metabolic Process Molecular Adaptor Activity	Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Musculoskeletal Movement Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Epithelial Fluid Transport Platelet Dense Granule Membrane Calcium Ion Transmembrane Transporter Activity Platelet Dense Tubular Network Membrane Calcium Import Into The Mitochondrion Calcineurin Complex Voluntary Musculoskeletal Movement Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Calcium Channel Inhibitor Activity Cell Morphogenesis Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Inositol 1,4,5 Trisphosphate Binding Negative Regulation Of Amino Acid Transport CGMP-dependent Protein Kinase Activity Mitogen-activated Protein Kinase P38 Binding Negative Regulation Of Inositol Phosphate Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Testosterone Biosynthetic Process Relaxation Of Smooth Muscle Negative Regulation Of Glutamate Secretion Relaxation Of Vascular Associated Smooth Muscle Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Peroxisome Proliferator Activated Receptor Binding Podocyte Development PR-DUB Complex Lung Saccule Development Bone Marrow Development Regulation Of Kidney Size Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway CGMP Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway Mitochondrial Calcium Ion Transmembrane Transport Negative Regulation Of Calcium-mediated Signaling Regulation Of Biological Quality Regulation Of Secretion By Cell Positive Regulation Of Circadian Rhythm Relaxation Of Muscle Collateral Sprouting Negative Regulation Of Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
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