PRKG1 and RGS2

Number of citations of the paper that reports this interaction (PubMedID 14608379)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		PRKG1	RGS2
Description		protein kinase cGMP-dependent 1	regulator of G protein signaling 2
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Sarcolemma	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase P38 Binding Protein Serine Kinase Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Adenylate Cyclase Inhibitor Activity Beta-tubulin Binding
	Biological Process	Neuron Migration Protein Phosphorylation Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Spermatid Development Heart Development Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Glutamate Secretion Negative Regulation Of Smooth Muscle Cell Migration Dendrite Development CGMP-mediated Signaling Cerebellum Development Actin Cytoskeleton Organization Forebrain Development Vasodilation Positive Regulation Of Circadian Rhythm Regulation Of GTPase Activity Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Contraction Collateral Sprouting Relaxation Of Vascular Associated Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Platelet Aggregation Bone Growth Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Testosterone Biosynthetic Process	Response To Amphetamine Regulation Of Translation G Protein-coupled Receptor Signaling Pathway Spermatogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of JNK Cascade Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		Ca2+ pathway	G alpha (q) signalling events
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 34101054) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophilic esophagitis ( 34506852) Gait rhythm ( 26219847) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol levels in HIV infection ( 33109212) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure ( 32902719) Triglyceride levels x loop diuretics use interaction ( 31806883)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		40 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP VHL WDR77 ZNF646	61 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		5592	5997
HPRD ID		08910	02917
Ensembl ID		ENSG00000185532	ENSG00000116741
Uniprot IDs		B1ALS0 Q13976	P41220
PDB IDs		1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T 7LV3 7MBJ 7SSB 7T4T 7T4U 7T4V 7T4W	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Response To Ketone Positive Regulation Of Hormone Secretion Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Enzyme Binding Regulation Of System Process CGMP-mediated Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Relaxation Of Vascular Associated Smooth Muscle Positive Regulation Of Secretion Cellular Response To Testosterone Stimulus Relaxation Of Smooth Muscle Intracellular Signaling Cassette Epithelial Cell Differentiation Involved In Prostate Gland Development Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Response To Phorbol 13-acetate 12-myristate Response To Alcohol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anatomical Structure Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Hormone Secretion Response To Purine-containing Compound Epithelial Fluid Transport Regulation Of Smooth Muscle Cell Proliferation Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Protein Homotetramerization Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Negative Regulation Of Sequestering Of Calcium Ion Inositol 1,4,5 Trisphosphate Binding Z Disc Positive Regulation Of Bone Resorption Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Forskolin Sarcoplasmic Reticulum A Band Monoatomic Ion Channel Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Secretion By Cell Regulation Of Cardiac Muscle Hypertrophy Response To Forskolin Regulation Of Muscle Contraction Regulation Of Developmental Process CGMP Metabolic Process Molecular Adaptor Activity	Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Guanyl Nucleotide Binding Calyx Of Held G-protein Beta/gamma-subunit Complex Binding Cognition Nucleotide Binding Regulation Of Secretion By Cell Scaffold Protein Binding Protein-containing Complex Binding Learning Or Memory Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Regulation Of Transport Response To Ketone Regulation Of Secretion Enzyme Binding Histone H3T6 Kinase Activity Regulation Of Neurotransmitter Secretion Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Corticosterone Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Insulin Secretion Regulation Of Muscle System Process Regulation Of Muscle Contraction Response To Alcohol Regulation Of Protein Secretion System Process Response To Catecholamine Cytoplasm Nervous System Process Adrenergic Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Exocytosis Response To Hormone Cellular Localization Protein Kinase C Signaling Membrane Regulation Of Peptide Hormone Secretion Establishment Of Localization In Cell Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cellular Component Organization G Protein-coupled Receptor Signaling Pathway Centrosome Regulation Of Establishment Of Protein Localization Response To Psychosocial Stress Adenylate Cyclase Activator Activity Intracellular Protein Localization G Protein Activity
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