PRKG1 and NPR1

Number of citations of the paper that reports this interaction (PubMedID 12855709)
0

Data Source:
HPRD (two hybrid, in vitro)

		PRKG1	NPR1
Description		protein kinase cGMP-dependent 1	natriuretic peptide receptor 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Sarcolemma	Plasma Membrane Membrane Receptor Complex ANPR-A Receptor Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Kinase Activity Transferase Activity CGMP Binding Identical Protein Binding Mitogen-activated Protein Kinase P38 Binding Protein Serine Kinase Activity	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding
	Biological Process	Neuron Migration Protein Phosphorylation Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Spermatid Development Heart Development Negative Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Glutamate Secretion Negative Regulation Of Smooth Muscle Cell Migration Dendrite Development CGMP-mediated Signaling Cerebellum Development Actin Cytoskeleton Organization Forebrain Development Vasodilation Positive Regulation Of Circadian Rhythm Regulation Of GTPase Activity Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Contraction Collateral Sprouting Relaxation Of Vascular Associated Smooth Muscle Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Platelet Aggregation Bone Growth Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Regulation Of Testosterone Biosynthetic Process	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance
Pathways		Ca2+ pathway	Physiological factors
Drugs			Nitroprusside Nitroglycerin Isosorbide dinitrate Amyl Nitrite Erythrityl tetranitrate Nesiritide Ularitide
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Alcohol misuse (trauma interaction) ( 28265120) Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Appendicular lean mass ( 33097823) Arthritis (juvenile idiopathic) ( 34101054) Asthma ( 21907864) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Eosinophilic esophagitis ( 34506852) Gait rhythm ( 26219847) HDL cholesterol levels in HIV infection ( 33109212) Height ( 28552196 31562340) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol levels in HIV infection ( 33109212) Logical memory (delayed recall) in normal cognition ( 29274321) Loneliness (multivariate analysis) ( 27629369) Mammographic density (non-dense area) ( 25342443) Mitochondrial DNA copy number ( 30704525) Obesity-related traits ( 23251661) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Stroke ( 32693751) Systolic blood pressure ( 32902719) Triglyceride levels x loop diuretics use interaction ( 31806883)	Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)
Interacting Genes		40 interacting genes: ANXA7 AR ARHGEF15 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 IRAG1 ITPR1 LASP1 LMO2 MEOX2 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RBAK RGS2 RYR1 SELL SEPTIN3 SF1 SPP1 TNNT1 TRIM39-RPP21 TRIM54 TRPC3 VASP VHL WDR77 ZNF646	7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2
Entrez ID		5592	4881
HPRD ID		08910	00165
Ensembl ID		ENSG00000185532	ENSG00000169418
Uniprot IDs		B1ALS0 Q13976	A0A140VJE6 P16066
PDB IDs		1ZXA 3NMD 3OCP 3OD0 3OGJ 4KU7 4KU8 4QX5 4QXK 4R4L 4R4M 4Z07 5J48 5JAX 5JD7 5L0N 6BDL 6BG2 6C0T 7LV3 7MBJ 7SSB 7T4T 7T4U 7T4V 7T4W	8TG9 8TGA 9BCL 9BCN 9BCO 9BCP 9BCQ 9BCS 9BCV
Enriched GO Terms of Interacting Partners?		Response To Ketone Positive Regulation Of Hormone Secretion Regulation Of Muscle System Process Negative Regulation Of Muscle Contraction Enzyme Binding Regulation Of System Process CGMP-mediated Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Phosphatase Regulator Activity Myosin Phosphatase Regulator Activity Relaxation Of Vascular Associated Smooth Muscle Positive Regulation Of Secretion Cellular Response To Testosterone Stimulus Relaxation Of Smooth Muscle Intracellular Signaling Cassette Epithelial Cell Differentiation Involved In Prostate Gland Development Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Response To Phorbol 13-acetate 12-myristate Response To Alcohol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anatomical Structure Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Hormone Secretion Response To Purine-containing Compound Epithelial Fluid Transport Regulation Of Smooth Muscle Cell Proliferation Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Protein Homotetramerization Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Negative Regulation Of Sequestering Of Calcium Ion Inositol 1,4,5 Trisphosphate Binding Z Disc Positive Regulation Of Bone Resorption Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Forskolin Sarcoplasmic Reticulum A Band Monoatomic Ion Channel Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Secretion By Cell Regulation Of Cardiac Muscle Hypertrophy Response To Forskolin Regulation Of Muscle Contraction Regulation Of Developmental Process CGMP Metabolic Process Molecular Adaptor Activity	Hormone Receptor Binding CGMP-mediated Signaling Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Cyclic Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Vasodilation Vascular Process In Circulatory System Positive Regulation Of CGMP-mediated Signaling Circulatory System Process Cell Growth Involved In Cardiac Muscle Cell Development Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Cardiac Conduction System Development Bone Growth Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Protein-containing Complex Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Negative Regulation Of Blood Pressure Organ Growth Ribonucleotide Metabolic Process Intracellular Signaling Cassette Ribose Phosphate Metabolic Process Cardiac Muscle Tissue Development Purine Nucleotide Metabolic Process Developmental Growth Negative Regulation Of Collecting Lymphatic Vessel Constriction Signaling Receptor Binding Diuretic Hormone Activity Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Neuropeptide Signaling Pathway Neuropeptide Receptor Binding Response To 3-methylcholanthrene Purine-containing Compound Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion
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