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KCNA4 and ACTN2
Number of citations of the paper that reports this interaction (PMID
11389904
)
6
Data Source:
HPRD
(two hybrid, in vitro)
KCNA4
ACTN2
Gene Name
potassium channel, voltage gated shaker related subfamily A, member 4
actinin, alpha 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Voltage-gated Potassium Channel Complex
Integral Component Of Membrane
Axon
Extracellular Region
Cytosol
Cytoskeleton
Actin Filament
Focal Adhesion
Z Disc
Filopodium
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Dendritic Spine
Extracellular Vesicular Exosome
Molecular Function
Voltage-gated Potassium Channel Activity
Delayed Rectifier Potassium Channel Activity
Protein Binding
Potassium Ion Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
LIM Domain Binding
Thyroid Hormone Receptor Coactivator Activity
Titin Binding
Identical Protein Binding
Ion Channel Binding
Protein Dimerization Activity
Actin Filament Binding
FATZ Binding
Titin Z Domain Binding
Biological Process
Potassium Ion Transport
Synaptic Transmission
Regulation Of Ion Transmembrane Transport
Protein Homooligomerization
Potassium Ion Transmembrane Transport
Platelet Degranulation
Cell Adhesion
Synaptic Transmission
Blood Coagulation
Microspike Assembly
Muscle Filament Sliding
Platelet Activation
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transport
Focal Adhesion Assembly
Protein Homotetramerization
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Positive Regulation Of Potassium Ion Transmembrane Transporter Activity
Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Receptor Activity
Pathways
Potassium Channels
Voltage gated Potassium channels
Striated Muscle Contraction
Platelet degranulation
CREB phosphorylation through the activation of Ras
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Response to elevated platelet cytosolic Ca2+
CREB phosphorylation through the activation of CaMKII
Nephrin interactions
Platelet activation, signaling and aggregation
Unblocking of NMDA receptor, glutamate binding and activation
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Ras activation uopn Ca2+ infux through NMDA receptor
Transmission across Chemical Synapses
Post NMDA receptor activation events
Drugs
Diseases
GWAS
Protein-Protein Interactions
16 interactors:
ACTN2
CASK
DLG1
DLG2
DLG3
DLG4
DLGAP1
ERBB2IP
INADL
KCNA2
LNX1
NDUFA4L2
NEU1
SAT1
SNTA1
SNTG1
59 interactors:
ACTN3
ADAM12
ADORA2A
ANG
ATXN2
ATXN7
BRMS1L
CAMK2A
CAMK2D
CAMK2G
CAPN1
COIL
DISC1
DLG1
DLG4
EPS8L1
ERBB2IP
FAM154A
FBXL22
GRIN1
GRIN2B
ITGB3BP
KAT2B
KCNA4
KCNA5
KCNN2
LDB3
LRP12
LRRC7
MED14
MICALL2
MOS
MYOZ1
MYOZ2
MYOZ3
MYPN
NCOA2
NCOR1
NOS3
NR1I2
NRIP1
PALLD
PDLIM1
PDLIM3
PKD2
RAVER1
RPL35
RTP5
SELE
SNAI1
SNW1
SP100
SSX2IP
ST7
SYNPO2
TNN
TTN
UTRN
ZNF446
Entrez ID
3739
88
HPRD ID
01444
00019
Ensembl ID
ENSG00000182255
ENSG00000077522
Uniprot IDs
P22459
B2RCS5
P35609
Q59FD9
PDB IDs
1H8B
1HCI
1QUU
Enriched GO Terms of Interacting Partners
?
Receptor Localization To Synapse
Nucleotide Phosphorylation
Protein Localization To Synapse
Synaptic Transmission
Establishment Or Maintenance Of Apical/basal Cell Polarity
Cell-cell Signaling
Receptor Clustering
Regulation Of Ion Transmembrane Transport
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Regulation Of Membrane Potential
Nucleotide Metabolic Process
Regulation Of Ion Transport
Nucleobase-containing Small Molecule Metabolic Process
Establishment Or Maintenance Of Cell Polarity
Organophosphate Metabolic Process
Protein Localization To Membrane
Cell Communication
Cortical Actin Cytoskeleton Organization
Positive Regulation Of Potassium Ion Transport
Cortical Cytoskeleton Organization
Regulation Of Sodium Ion Transmembrane Transport
Positive Regulation Of Ion Transport
Cell Junction Assembly
Small Molecule Metabolic Process
Cell-cell Junction Organization
Muscle Contraction
Tight Junction Assembly
Signaling
Protein Homooligomerization
Muscle System Process
Cellular Component Assembly
Negative Regulation Of Phosphatase Activity
Regulation Of Vasoconstriction By Circulating Norepinephrine
Regulation Of Potassium Ion Transport
Regulation Of Sodium Ion Transport
Negative Regulation Of Dephosphorylation
Apical Junction Assembly
Cellular Protein Localization
Positive Regulation Of Ion Transmembrane Transport
Optic Nerve Structural Organization
Spermidine Acetylation
Basal Protein Localization
Action Potential
Sensory Perception Of Pain
Membrane Organization
Axon Guidance
Regulation Of Phosphatase Activity
Putrescine Catabolic Process
Protein Oligomerization
Cellular Localization
Cytoskeleton Organization
Regulation Of Ion Transport
Organelle Organization
Cell Communication
Actin Filament-based Process
Signaling
Cellular Component Assembly
Positive Regulation Of Cellular Metabolic Process
Regulation Of Ion Transmembrane Transport
Anatomical Structure Development
Synaptic Transmission
Positive Regulation Of Metabolic Process
Cell Development
Signal Transduction
Movement Of Cell Or Subcellular Component
Cell Differentiation
Cell-cell Signaling
Regulation Of Cellular Process
Rhythmic Process
Developmental Process
Regulation Of Transcription From RNA Polymerase II Promoter
Intracellular Receptor Signaling Pathway
Actin Cytoskeleton Organization
Anatomical Structure Morphogenesis
Protein Complex Assembly
Regulation Of Potassium Ion Transport
Striated Muscle Cell Differentiation
Regulation Of Signaling
Anatomical Structure Formation Involved In Morphogenesis
Response To Organic Substance
Regulation Of Sodium Ion Transport
Response To Abiotic Stimulus
Muscle System Process
Negative Regulation Of Transport
Striated Muscle Cell Development
Positive Regulation Of Cellular Biosynthetic Process
Myofibril Assembly
Establishment Or Maintenance Of Apical/basal Cell Polarity
Transcription Initiation From RNA Polymerase II Promoter
Cell Adhesion
Muscle Cell Development
Cellular Calcium Ion Homeostasis
Regulation Of Receptor Internalization
Regulation Of Cellular Response To Heat
Response To Stimulus
Regulation Of Histone Deacetylase Activity
Calcium Ion Homeostasis
Regulation Of Calcium Ion Transport
Locomotion
Negative Regulation Of Ion Transport
Tagcloud
?
actinin
barr
cd99
cdk8
dnajb2
e2f
e2f2
ebv
epstein
fatigue
hsp40
hybridized
indicative
infectious
infective
irritability
isg20
malaise
microarrays
mononucleosis
oligonucleotides
pbmc
persist
pilot
recovered
resolve
somnolence
spotted
uneventfully
Tagcloud (Difference)
?
actinin
barr
cd99
cdk8
dnajb2
e2f
e2f2
ebv
epstein
fatigue
hsp40
hybridized
indicative
infectious
infective
irritability
isg20
malaise
microarrays
mononucleosis
oligonucleotides
pbmc
persist
pilot
recovered
resolve
somnolence
spotted
uneventfully
Tagcloud (Intersection)
?