KCNA4 and PATJ

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		KCNA4	PATJ
Description		potassium voltage-gated channel subfamily A member 4	PATJ crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Monoatomic Ion Channel Complex Cell Projection Axon Initial Segment Dendritic Spine	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Protein Binding
	Biological Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly
Pathways		Voltage gated Potassium channels	Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs		Enflurane Promethazine Miconazole Arginineamide Dalfampridine
Diseases
GWAS		Adult body size ( 32376654) Diastolic blood pressure ( 27841878) Luteinizing hormone levels in polycystic ovary syndrome ( 26284813) Menarche (age at onset) ( 27182965) Polycystic ovary syndrome ( 26284813) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		16 interacting genes: ACTN2 CASK COXFA4L2 DLG1 DLG2 DLG3 DLG4 DLGAP1 ERBIN KCNA2 LNX1 NEU1 PATJ SAT1 SNTA1 SNTG1	35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3
Entrez ID		3739	10207
HPRD ID		01444	04434
Ensembl ID		ENSG00000182255	ENSG00000132849
Uniprot IDs		P22459	A0A2R8Y549 Q8NI35
PDB IDs			1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Cell Junction Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Ionotropic Glutamate Receptor Binding Postsynaptic Density Membrane GMP Kinase Activity Receptor Localization To Synapse GDP Metabolic Process Receptor Clustering Juxtaparanode Region Of Axon Protein Localization To Synapse Glutamatergic Synapse Protein Localization To Cell Junction Kinase Binding GMP Metabolic Process Basolateral Plasma Membrane Syntrophin Complex Cell Adhesion Protein Localization To Membrane Chemical Synaptic Transmission Neuron Projection Trans-synaptic Signaling Synapse Synaptic Signaling Plasma Membrane Cell Communication Adherens Junction Anchoring Junction Regulation Of Membrane Potential Nucleoside Monophosphate Metabolic Process Postsynaptic Specialization Ribonucleoside Diphosphate Metabolic Process Voltage-gated Potassium Channel Complex PDZ Domain Binding Nucleoside Diphosphate Metabolic Process Cellular Response To Potassium Ion Postsynaptic Density Basement Membrane Dystrophin-associated Glycoprotein Complex Localization Within Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Nervous System Development Response To Potassium Ion Cell-cell Signaling Bicellular Tight Junction Signaling Transmembrane Transporter Binding	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation
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