ARHGAP26 and PKN1

Number of citations of the paper that reports this interaction (PubMedID 11432776)
0

Data Source:
HPRD (in vivo, in vitro)

		ARHGAP26	PKN1
Description		Rho GTPase activating protein 26	protein kinase N1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endosome Cytosol Cytoskeleton Focal Adhesion Endosome Membrane Membrane Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex
	Molecular Function	GTPase Activator Activity Protein Binding Phospholipid Binding Protein-macromolecule Adaptor Activity	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity
	Biological Process	Mitophagy Signal Transduction Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Pulse pressure ( 27841878) Septic shock resolution ( 32755526) Suicide attempt severity in mood disorders ( 33783297) Waist circumference ( 28552196)	Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		8 interacting genes: CDC42 CDC42EP2 INSR PKN1 PKN3 PTK2 RHOA SRPK1	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		23092	5585
HPRD ID		05643	03019
Ensembl ID		ENSG00000145819	ENSG00000123143
Uniprot IDs		A0A0S2Z536 A0A2R8YGB3 Q9UNA1	Q16512
PDB IDs		1UGV	1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Kinase Activity Kinase Activity Establishment Of Cell Polarity Positive Regulation Of Pseudopodium Assembly ATP Binding Phosphate-containing Compound Metabolic Process Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Ameboidal-type Cell Migration Cell Migration Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Locomotion Positive Regulation Of Organelle Organization Polarized Epithelial Cell Differentiation Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Midbody Signal Transduction Cell Motility Positive Regulation Of Cell Migration Dendritic Spine Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelial Cell Migration Positive Regulation Of Cell Motility Plasma Membrane Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Positive Regulation Of Locomotion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cytokinesis Neuron Projection Organization Substantia Nigra Development Postsynapse Organization Membrane Invagination Actin Filament Organization Positive Regulation Of Cell Cycle Process Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion
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