ARHGAP26 and PKN3

Number of citations of the paper that reports this interaction (PubMedID 11432776)
0

Data Source:
HPRD (two hybrid, in vivo)

		ARHGAP26	PKN3
Description		Rho GTPase activating protein 26	protein kinase N3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endosome Cytosol Cytoskeleton Focal Adhesion Endosome Membrane Membrane Anchoring Junction	Nucleus Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Phospholipid Binding Protein-macromolecule Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Protein Serine Kinase Activity
	Biological Process	Mitophagy Signal Transduction Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction	Protein Phosphorylation Signal Transduction Epithelial Cell Migration Intracellular Signal Transduction
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	RHO GTPases activate PKNs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) LDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Myocardial infarction ( 33532862) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Pulse pressure ( 27841878) Septic shock resolution ( 32755526) Suicide attempt severity in mood disorders ( 33783297) Waist circumference ( 28552196)	Apolipoprotein B levels ( 32203549) Asthma ( 31361310) Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457) Gamma glutamyl transferase levels ( 29403010 33339817) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: CDC42 CDC42EP2 INSR PKN1 PKN3 PTK2 RHOA SRPK1	9 interacting genes: ARHGAP10 ARHGAP26 GOLGA2 KRT31 MTUS2 PLD1 PNMA1 TFIP11 VPS52
Entrez ID		23092	29941
HPRD ID		05643	17856
Ensembl ID		ENSG00000145819	ENSG00000160447
Uniprot IDs		A0A0S2Z536 A0A2R8YGB3 Q9UNA1	Q6P5Z2
PDB IDs		1UGV
Enriched GO Terms of Interacting Partners?		Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Kinase Activity Kinase Activity Establishment Of Cell Polarity Positive Regulation Of Pseudopodium Assembly ATP Binding Phosphate-containing Compound Metabolic Process Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Ameboidal-type Cell Migration Cell Migration Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Cytoskeleton Organization Regulation Of Locomotion Positive Regulation Of Organelle Organization Polarized Epithelial Cell Differentiation Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Polarity Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Cytoskeleton Organization Midbody Signal Transduction Cell Motility Positive Regulation Of Cell Migration Dendritic Spine Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelial Cell Migration Positive Regulation Of Cell Motility Plasma Membrane Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Positive Regulation Of Locomotion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cytokinesis Neuron Projection Organization Substantia Nigra Development Postsynapse Organization Membrane Invagination Actin Filament Organization Positive Regulation Of Cell Cycle Process Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway	Syntaxin Binding Endosome Embryonic Ectodermal Digestive Tract Development Endosome Membrane
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