BUD23 and DNMT3B

Number of citations of the paper that reports this interaction (PubMedID 30535232)
0

Data Source:
BioGRID (pull down)

		BUD23	DNMT3B
Description		BUD23 rRNA methyltransferase and ribosome maturation factor	DNA methyltransferase 3 beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Catalytic Complex
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity RRNA (guanine) Methyltransferase Activity Transferase Activity Protein Heterodimerization Activity	DNA Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Chromatin Organization RRNA Processing Methylation Ribosome Biogenesis RRNA (guanine-N7)-methylation Positive Regulation Of RRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression Methylation
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis
Drugs			Decitabine
Diseases			Other humoral immunodeficiencies, including the following three diseases: Immunodeficiency, centromeric instability, facial anomalies (ICF)-syndrome; kappa light-chain deficiency; Ig heavy chain gene deletions
GWAS			Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 23128233) Iron status biomarkers (iron levels) ( 28334935) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Nicotine dependence ( 28972577) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Total cholesterol levels ( 30275531)
Interacting Genes		6 interacting genes: CEBPA DNMT3B OAS1 PKN1 UBC VCP	39 interacting genes: BAZ2A BUD23 CBX1 CBX3 CBX5 CMTM6 CUL4B DDB1 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 H3C1 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS1 ZBTB18
Entrez ID		114049	1789
HPRD ID		15659	04209
Ensembl ID		ENSG00000071462	ENSG00000088305
Uniprot IDs		O43709	A0A8Q3SIG2 Q9UBC3
PDB IDs		6G4W 7WTS 7WTT 7WTU 7WTV 7WTW	3FLG 3QKJ 5CIU 5NR3 5NRR 5NRS 5NRV 5NV0 5NV2 5NV7 5NVO 6KDA 6KDB 6KDL 6KDP 6KDT 6PA7 6R3E 6U8P 6U8V 6U8W 6U8X 6U90 6U91 7O45 7V0E 7X9D 8EIH 8EII 8EIJ 8EIK 8XEE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Respiration Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Immune System Process CHOP-C/EBP Complex Histone Deacetylase Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 Multicellular Organismal-level Homeostasis C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Regulation Of Cellular Respiration Regulation Of Generation Of Precursor Metabolites And Energy Histone H3T11 Kinase Activity Flavin Adenine Dinucleotide Catabolic Process VCP-NSFL1C Complex Cellular Response To Arsenite Ion Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Biosynthetic Process White Fat Cell Proliferation Negative Regulation Of IP-10 Production Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production 2'-5'-oligoadenylate Synthetase Activity Cytoplasm Protein Quality Control BAT3 Complex Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Regulation Of Ribonuclease Activity Positive Regulation Of Protein Deubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Carbohydrate Homeostasis Response To Phenylpropanoid Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Protein-containing Complex Intracellular Signal Transduction Positive Regulation Of Protein Catabolic Process Fat Cell Proliferation Interleukin-27-mediated Signaling Pathway	Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Heterochromatin Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Pericentric Heterochromatin Constitutive Heterochromatin Formation Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Silencing Complex Negative Regulation Of RNA Metabolic Process Facultative Heterochromatin Formation Epigenetic Programming Of Gene Expression Nucleoplasm Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Negative Regulation Of Metabolic Process DNA Damage Response Cellular Response To Stress Regulation Of Gene Expression RDNA Heterochromatin Formation Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Chromosome, Centromeric Region Regulation Of Macromolecule Metabolic Process Chromosome Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Complex Chromosome, Telomeric Region Epigenetic Programming In The Zygotic Pronuclei Regulation Of Chromosome Condensation Regulation Of Primary Metabolic Process Chromosomal DNA Methylation Maintenance Following DNA Replication Condensed Nuclear Chromosome Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity NoRC Complex Methylation
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