WBSCR22 and OAS1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		WBSCR22	OAS1
Gene Name		Williams Beuren syndrome chromosome region 22	2-5-oligoadenylate synthetase 1, 40/46kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleolus Cytoplasm	Extracellular Region Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol
	Molecular Function	Methyltransferase Activity Poly(A) RNA Binding	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated RRNA Processing Biological_process Chromatin Modification Methylation	Glucose Metabolic Process Purine Nucleotide Biosynthetic Process Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Glucose Homeostasis Negative Regulation Of Viral Genome Replication Protein Oligomerization Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Glycemic traits ( 23575436) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		3 interactors: OAS1 PKN1 VCP	6 interactors: ACTN1 EXOC5 PRMT6 RPL30 TRIM27 WBSCR22
Entrez ID		114049	4938
HPRD ID		15659	08879
Ensembl ID		ENSG00000071462	ENSG00000089127
Uniprot IDs		C9K060 O43709	P00973
PDB IDs			4IG8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Ribonuclease Activity Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Deubiquitination Protein Hexamerization Histone H3-T11 Phosphorylation Protein Oligomerization Regulation Of Catalytic Activity Cellular Response To Interferon-alpha Aggresome Assembly Translesion Synthesis Response To Interferon-alpha Postreplication Repair Hyperosmotic Response Response To Stress Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification ER-associated Ubiquitin-dependent Protein Catabolic Process Activation Of JUN Kinase Activity Histone Phosphorylation Protein Complex Assembly Carbohydrate Metabolic Process Negative Regulation Of Viral Genome Replication Peptidyl-threonine Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Response To Heat Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Viral Genome Replication Positive Regulation Of JUN Kinase Activity Negative Regulation Of Viral Process Cellular Nitrogen Compound Metabolic Process Regulation Of JUN Kinase Activity JNK Cascade Signal Transduction Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Osmotic Stress Endoplasmic Reticulum Unfolded Protein Response Activation Of Cysteine-type Endopeptidase Activity Cellular Response To Stress Positive Regulation Of Catalytic Activity ER To Golgi Vesicle-mediated Transport Cellular Response To Unfolded Protein	Secretion By Cell Organelle Organization Secretion Histone H3-R2 Methylation Negative Regulation Of Interleukin-2 Secretion Protein Localization Establishment Of Localization In Cell Protein Localization To Tight Junction RNA Biosynthetic Process Cellular Localization Negative Regulation Of Calcium Ion Import Interferon-gamma Secretion Protein Localization To Cell Junction Actin Filament Organization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Exocytosis Histone H4-R3 Methylation Protein Transport Negative Regulation Of Viral Release From Host Cell Vesicle-mediated Transport RNA Metabolic Process Establishment Of Protein Localization Peptidyl-arginine N-methylation Methylation Actin Crosslink Formation Intracellular Transport Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Gene Expression Histone Arginine Methylation Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Peptidyl-arginine Methylation Regulation Of Calcium Ion Import Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Viral Process Focal Adhesion Assembly Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Actin Cytoskeleton Organization Chromatin Modification Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Actin Filament-based Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Arp2/3 Complex-mediated Actin Nucleation
Tagcloud ?		a549 adm antitumor attenuates camptothecin cddp cddpr chemosensitivity doxorubicin ethyl fluorouracil fu h1299 h460 h460nc harboring hydroxycamptothecin knockdown marginally merm1 metabolite mitomycin mmc nc paclitaxel ptx shrna sn xenograft	5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Difference) ?		a549 adm antitumor attenuates camptothecin cddp cddpr chemosensitivity doxorubicin ethyl fluorouracil fu h1299 h460 h460nc harboring hydroxycamptothecin knockdown marginally merm1 metabolite mitomycin mmc nc paclitaxel ptx shrna sn xenograft	5as activate agrees antiviral baculovirus capability compelling considerably contrary dsrna harbors homogeneity intracellularly messengers mutagenesis oas3 oligoadenylate oligoadenylates purify redefines restrict rnase saxs scattering sensors synthesize synthesizes synthetase
Tagcloud (Intersection) ?