POU6F2 and PADI4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU6F2	PADI4
Description		POU class 6 homeobox 2	peptidyl arginine deiminase 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Protein-arginine Deiminase Activity Calcium Ion Binding Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding Histone Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R26 Arginine Deiminase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Visual Perception	Immune System Process Chromatin Organization Nucleosome Assembly Chromatin Remodeling Stem Cell Population Maintenance Protein Modification Process Post-translational Protein Modification Innate Immune Response
Pathways			Chromatin modifying enzymes
Drugs			Citrulline Azithromycin Tetracycline Streptomycin N-[(1S)-1-(aminocarbonyl)-4-(ethanimidoylamino)butyl]benzamide Chlortetracycline
Diseases
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Caffeine consumption from tea ( 33287642) Feeling hurt ( 29500382) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 30054594 31959993) Motion sickness ( 25628336) Refractive error ( 32231278) Tea consumption ( 31046077)	Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 18849993) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) IgA nephropathy ( 25305756 32912934) Rheumatoid arthritis ( 21452313 21505073 23143596 24390342 30423114 30572963 32723749) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		143 interacting genes: ACTN3 AIRIM ANKRD10 ARHGEF6 ASB13 BANP BFSP2 BHLHE40 C5 CCHCR1 CCNC CCNK CDC23 CDC37 CDKN2C CHAF1A CIB3 CINP CSNK2A1 CSTF2 CTNNA3 DDX6 DTNB DYDC1 EBF1 EIF3F EIF4EBP1 EPHB6 FHL2 FNDC3B FOSB GCM2 GLIS2 GMEB2 GOLGA6L9 HGS HIVEP1 HNF1B HOXC5 HOXC8 HSPA4 IGFN1 IMPDH2 IQUB IRX4 ISX KDF1 KIF5B KLHL11 KPNA5 KPNA6 KRTAP8-1 L3MBTL2 LARP4 LMNB2 LMO3 LNX1 LONRF1 MAGEA12 MAPK9 MEIS2 MIEN1 MLLT10 MORF4L2 MSRB3 MSX2 MYL7 MYO15B NEUROG3 NFYC NKX3-2 NME7 NUP62CL OAZ3 OIP5 OPLAH OPTN PADI4 PARVG PDE6H PIBF1 PKN1 PM20D2 POLR3C POU2F1 PPIL1 PPIP5K2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAD23B RBM39 RBPMS RELA SIX1 SMAD5 SMYD1 SORL1 SOX10 SSUH2 STAC STRA8 TBX6 TCEA2 TENT5B THADA THAP1 TLX2 TLX3 TNPO2 TNXB TP53BP1 TRIM73 TRIML2 TSC1 TSEN15 TTC19 TTC23 UBAC1 UFSP1 VAX2 VENTX VEZF1 VPS9D1 XPOT ZBTB24 ZBTB4 ZFHX2 ZFHX3 ZFP1 ZFP91 ZIM2 ZMYND12 ZNF148 ZNF319 ZNF34 ZNF384 ZNF410 ZNF574	12 interacting genes: ANXA4 APP FBXO25 H3C15 HDAC2 LRRK2 MDM2 NPM1 POU6F2 RYBP SMURF1 TRIB3
Entrez ID		11281	23569
HPRD ID		10162	05635
Ensembl ID		ENSG00000106536	ENSG00000159339
Uniprot IDs		A0A6E1XZL4 P78424	Q9UM07
PDB IDs			1WD8 1WD9 1WDA 2DEW 2DEX 2DEY 2DW5 3APM 3APN 3B1T 3B1U 4DKT 4X8C 4X8G 5N0M 5N0Y 5N0Z 5N1B 8GOD 8R8U 8R8V 8SMK 8SML
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Sequence-specific Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Protein Binding Chromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pattern Specification Process Negative Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Branch Elongation Involved In Ureteric Bud Branching Stem Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Import Signal Receptor Activity Animal Organ Development Activation Of Meiosis Nuclear Localization Sequence Binding DNA-templated Transcription	Positive Regulation Of Proteolysis Regulation Of Proteolysis Negative Regulation Of Signal Transduction Cellular Response To Catecholamine Stimulus Response To Catecholamine Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process NF-kappaB Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Dopamine Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Manganese Ion Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Manganese Ion Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Golgi-associated Vesicle Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor Production Regulation Of RNA Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Programmed Cell Death
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