POU6F2 and NKX3-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POU6F2	NKX3-2
Description		POU class 6 homeobox 2	NK3 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Visual Perception	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Determination Of Left/right Symmetry Cell Differentiation Pancreas Development Negative Regulation Of Chondrocyte Differentiation Middle Ear Morphogenesis Negative Regulation Of Apoptotic Process Animal Organ Development Spleen Development Animal Organ Formation Skeletal System Morphogenesis Embryonic Skeletal System Development Digestive System Development Intestinal Epithelial Cell Development
Pathways			Regulation of RUNX2 expression and activity
Drugs
Diseases			Spondylo-megaepiphyseal-metaphyseal dysplasia
GWAS		Adult body size ( 32376654) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Caffeine consumption from tea ( 33287642) Feeling hurt ( 29500382) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Intraocular pressure ( 29785010 30054594 31959993) Motion sickness ( 25628336) Refractive error ( 32231278) Tea consumption ( 31046077)	Metabolite levels ( 23823483) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		143 interacting genes: ACTN3 AIRIM ANKRD10 ARHGEF6 ASB13 BANP BFSP2 BHLHE40 C5 CCHCR1 CCNC CCNK CDC23 CDC37 CDKN2C CHAF1A CIB3 CINP CSNK2A1 CSTF2 CTNNA3 DDX6 DTNB DYDC1 EBF1 EIF3F EIF4EBP1 EPHB6 FHL2 FNDC3B FOSB GCM2 GLIS2 GMEB2 GOLGA6L9 HGS HIVEP1 HNF1B HOXC5 HOXC8 HSPA4 IGFN1 IMPDH2 IQUB IRX4 ISX KDF1 KIF5B KLHL11 KPNA5 KPNA6 KRTAP8-1 L3MBTL2 LARP4 LMNB2 LMO3 LNX1 LONRF1 MAGEA12 MAPK9 MEIS2 MIEN1 MLLT10 MORF4L2 MSRB3 MSX2 MYL7 MYO15B NEUROG3 NFYC NKX3-2 NME7 NUP62CL OAZ3 OIP5 OPLAH OPTN PADI4 PARVG PDE6H PIBF1 PKN1 PM20D2 POLR3C POU2F1 PPIL1 PPIP5K2 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E QRICH1 RAD23B RBM39 RBPMS RELA SIX1 SMAD5 SMYD1 SORL1 SOX10 SSUH2 STAC STRA8 TBX6 TCEA2 TENT5B THADA THAP1 TLX2 TLX3 TNPO2 TNXB TP53BP1 TRIM73 TRIML2 TSC1 TSEN15 TTC19 TTC23 UBAC1 UFSP1 VAX2 VENTX VEZF1 VPS9D1 XPOT ZBTB24 ZBTB4 ZFHX2 ZFHX3 ZFP1 ZFP91 ZIM2 ZMYND12 ZNF148 ZNF319 ZNF34 ZNF384 ZNF410 ZNF574	4 interacting genes: HDAC1 POU6F2 SMAD1 SMAD4
Entrez ID		11281	579
HPRD ID		10162	09075
Ensembl ID		ENSG00000106536	ENSG00000109705
Uniprot IDs		A0A6E1XZL4 P78424	P78367
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Sequence-specific Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Protein Binding Chromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Pattern Specification Process Negative Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Branch Elongation Involved In Ureteric Bud Branching Stem Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Import Signal Receptor Activity Animal Organ Development Activation Of Meiosis Nuclear Localization Sequence Binding DNA-templated Transcription	Negative Regulation Of Muscle Cell Differentiation Heteromeric SMAD Protein Complex SMAD Protein Complex Regulation Of Muscle Cell Differentiation I-SMAD Binding Cardiac Conduction System Development SMAD Protein Signal Transduction Transcription Regulator Complex Endoderm Development Cellular Response To Growth Factor Stimulus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Striated Muscle Cell Differentiation Response To Growth Factor Chromatin Transcription Corepressor Binding Embryonic Digit Morphogenesis Positive Regulation Of MiRNA Transcription Embryonic Pattern Specification Cardiac Muscle Tissue Development Positive Regulation Of MiRNA Metabolic Process Intracellular Iron Ion Homeostasis Regulation Of MiRNA Transcription Regulation Of Striated Muscle Cell Differentiation Regulation Of MiRNA Metabolic Process BMP Signaling Pathway Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Stem Cell Differentiation Krueppel-associated Box Domain Binding Negative Regulation Of Cell Differentiation Striated Muscle Tissue Development Osteoblast Differentiation Homomeric SMAD Protein Complex DNA-binding Transcription Factor Activity Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein-containing Complex Protein Lysine Delactylase Activity Fungiform Papilla Formation Mesodermal Cell Fate Commitment Muscle Tissue Development Osteoblast Fate Commitment Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis
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