GRSF1 and HCFC2

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		GRSF1	HCFC2
Description		G-rich RNA sequence binding factor 1	host cell factor C2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Histone Methyltransferase Complex MLL1/2 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Viral Process Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of DNA-templated Transcription Antiviral Innate Immune Response Immune Response Involved In Response To Exogenous DsRNA
Pathways		Viral mRNA Translation Mitochondrial RNA degradation	Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Type 2 diabetes ( 30718926)	PR interval ( 32439900)
Interacting Genes		55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3	2 interacting genes: GRSF1 KMT2A
Entrez ID		2926	29915
HPRD ID		07276	06393
Ensembl ID		ENSG00000132463	ENSG00000111727
Uniprot IDs		Q12849	Q9Y5Z7
PDB IDs		2LMI 4QU6 4QU7
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development	Membrane Depolarization Response To Bleomycin Collagen Type VI Trimer Apoptotic Nuclear Changes Rhythmic Process Regulation Of Collagen Fibril Organization Skeletal Muscle Tissue Growth Limb Joint Morphogenesis Mitochondrial Depolarization Multicellular Organismal Locomotion Skeletal Muscle Fiber Differentiation Response To Polyamine Macromolecule Reduction Of Food Intake In Response To Dietary Excess Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Caveola Assembly Response To Light Stimulus Circadian Rhythm Homeostasis Of Number Of Cells Endoplasmic Reticulum Lumen Fat Cell Proliferation G-quadruplex RNA Binding Anterior/posterior Pattern Specification Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process Regionalization T-helper 2 Cell Differentiation Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Heterochromatin Formation Lamellar Body Plasma Membrane Raft Assembly Nucleobase-containing Compound Catabolic Process Platelet-derived Growth Factor Binding Mitochondrion Membrane Raft Assembly Plasma Membrane Raft Organization Pattern Specification Process Regulation Of Short-term Neuronal Synaptic Plasticity Ribonucleoprotein Granule Histone H3K4 Methyltransferase Activity Regulation Of Membrane Potential Response To Radiation 2-oxoglutarate Metabolic Process Definitive Hemopoiesis
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