GRSF1 and ISYNA1

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		GRSF1	ISYNA1
Description		G-rich RNA sequence binding factor 1	inositol-3-phosphate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex	Cytoplasm Cytosol
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Inositol-3-phosphate Synthase Activity Protein Binding Isomerase Activity
	Biological Process	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing	Inositol Biosynthetic Process Lipid Metabolic Process Phospholipid Biosynthetic Process
Pathways		Viral mRNA Translation Mitochondrial RNA degradation	Synthesis of IP2, IP, and Ins in the cytosol
Drugs			2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate 2-Deoxy-Glucitol-6-Phosphate Glycerin
Diseases
GWAS		Type 2 diabetes ( 30718926)	Alzheimer's disease (late onset) ( 30820047) Breast cancer ( 23535729) Heel bone mineral density ( 30598549)
Interacting Genes		55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3	6 interacting genes: DUSP14 GRSF1 OGT POT1 PPP2CA TRAF4
Entrez ID		2926	51477
HPRD ID		07276	17163
Ensembl ID		ENSG00000132463	ENSG00000105655
Uniprot IDs		Q12849	A0A140VK73 Q9NPH2
PDB IDs		2LMI 4QU6 4QU7
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development	Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Purine Nucleotide Metabolic Process Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Mitochondrial RNA Catabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Phosphoprotein Phosphatase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Chromosome Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomere Assembly Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Shelterin Complex Mitochondrial RNA Catabolic Process Regulation Of Primary Metabolic Process RNA Catabolic Process Carbon Catabolite Regulation Of Transcription Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Macromolecule Metabolic Process G-quadruplex RNA Binding DEAD/H-box RNA Helicase Binding Protein Serine/threonine Phosphatase Complex Peptidyl-threonine Dephosphorylation Regulation Of Transcription By Glucose Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Thioesterase Binding G-rich Strand Telomeric DNA Binding
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