GRSF1 and UBE3C

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		GRSF1	UBE3C
Description		G-rich RNA sequence binding factor 1	ubiquitin protein ligase E3C
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex	Proteasome Complex
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing	Autophagosome Assembly Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Phosphatidylinositol Phosphate Biosynthetic Process Protein K48-linked Ubiquitination
Pathways		Viral mRNA Translation Mitochondrial RNA degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Type 2 diabetes ( 30718926)	Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)
Interacting Genes		55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3	17 interacting genes: APP BIRC6 CAND2 CCNB1 DOT1L GOLGA2 GRSF1 MTA2 PIK3C3 PSMC5 PSMD2 TLK1 TP73 UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		2926	9690
HPRD ID		07276	15604
Ensembl ID		ENSG00000132463	ENSG00000009335
Uniprot IDs		Q12849	Q15386
PDB IDs		2LMI 4QU6 4QU7	6K2C
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development	Ubiquitin Conjugating Enzyme Activity Macromolecule Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Protein Modification Process Proteolysis Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Positive Regulation Of Protein Metabolic Process Protein Tetramerization Post-translational Protein Modification Transferase Activity Proteasome Accessory Complex Protein Polyubiquitination Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus ATP Binding Catabolic Process TBP-class Protein Binding Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Spindle Pole Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex DNA-binding Transcription Factor Binding Protein K11-linked Ubiquitination
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