GRSF1 and NOP53

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		GRSF1	NOP53
Description		G-rich RNA sequence binding factor 1	NOP53 ribosome biogenesis factor
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol RDNA Heterochromatin
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	P53 Binding RNA Binding Protein Binding 5S RRNA Binding Identical Protein Binding
	Biological Process	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing	Ribosomal Large Subunit Assembly Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Phosphorylation DNA Repair RRNA Processing DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of RIG-I Signaling Pathway Ribosome Biogenesis Regulation Of Apoptotic Process Protein Stabilization Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Localization To Nucleolus Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration Protein Localization To Nucleoplasm
Pathways		Viral mRNA Translation Mitochondrial RNA degradation
Drugs
Diseases
GWAS		Type 2 diabetes ( 30718926)
Interacting Genes		55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3	15 interacting genes: CCDC136 CDKN2A CEP70 CFTR GRSF1 HAP1 HMGB2 OGT PPP1CA PSMA1 SPTBN1 SRPK2 TP53 TSPYL2 UPF2
Entrez ID		2926	29997
HPRD ID		07276	16142
Ensembl ID		ENSG00000132463	ENSG00000105373
Uniprot IDs		Q12849	Q9NZM5
PDB IDs		2LMI 4QU6 4QU7	8FKZ 8FL2 8FL3 8FL4 8FL6 8FL7 8FLA 8FLB 8FLD 8FLE 8INE 8INF 8IPX 8IPY 8IR3
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development	Nucleolus 14-3-3 Protein Binding Autophagy Of Mitochondrion Protein-containing Complex Cytoplasm Regulation Of Carbohydrate Catabolic Process Regulation Of Cellular Localization Nucleus Organization Organelle Organization MDM2/MDM4 Family Protein Binding Replicative Senescence Developmental Process Regulation Of Glucose Metabolic Process Nuclear Body Organization Autophagy RRNA Transcription Entrainment Of Circadian Clock By Photoperiod Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Negative Regulation Of DNA Replication Disordered Domain Specific Binding Negative Regulation Of Proteolysis Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Gene Expression Cellular Component Assembly Negative Regulation Of Cell Growth Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Cellular Component Organization Anatomical Structure Formation Involved In Morphogenesis Regulation Of Programmed Necrotic Cell Death Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transporter Activity Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Negative Regulation Of Growth Nucleic Acid Metabolic Process RNA Metabolic Process Ligase Inhibitor Activity Regulation Of Cell Communication Nucleus Regulation Of Signaling Catabolic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Double-strand Break Repair Negative Regulation Of Helicase Activity
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