GRSF1 and RAB3A

Number of citations of the paper that reports this interaction (PubMedID 32645484)
0

Data Source:
BioGRID (two hybrid)

		GRSF1	RAB3A
Description		G-rich RNA sequence binding factor 1	RAB3A, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule Mitochondrial Nucleoid Ribonucleoprotein Complex	Acrosomal Vesicle Cytoplasm Lysosome Endosome Cytosol Plasma Membrane Synaptic Vesicle Membrane Transport Vesicle Axon Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cell Projection Terminal Bouton Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse Postsynapse Extracellular Vesicle
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein-macromolecule Adaptor Activity GTP-dependent Protein Binding Myosin V Binding Metal Ion Binding
	Biological Process	Mitochondrial RNA Catabolic Process Positive Regulation Of Mitochondrial RNA Catabolic Process MRNA Processing TRNA Processing Anterior/posterior Pattern Specification Morphogenesis Of Embryonic Epithelium Regulation Of RNA Splicing	Plasma Membrane Repair Respiratory System Process Exocytosis Mitochondrion Organization Neuromuscular Synaptic Transmission Axonogenesis Post-embryonic Development Protein Transport Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Calcium-ion Regulated Exocytosis Regulation Of Exocytosis Insulin Secretion Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Synaptic Vesicle Recycling Constitutive Secretory Pathway Regulated Exocytosis Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Transport Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Establishment Of Localization In Cell Acrosomal Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Clustering Regulation Of Presynaptic Dense Core Granule Exocytosis Positive Regulation Of Regulated Secretory Pathway Regulation Of Plasma Membrane Repair
Pathways		Viral mRNA Translation Mitochondrial RNA degradation	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Type 2 diabetes ( 30718926)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		55 interacting genes: AUP1 BTBD6 CNRIP1 COMMD1 CYC1 DACT1 EIF1B ERO1A FADS2 FNTA FYN GSE1 GTF2E2 HCFC2 HIVEP3 ISYNA1 MAP6 MIR1-2 MIR106B MIR18B MIR200B MIR200C MIR205 MIR25 MIR31 MIR451A MIR9-1 MIR9-2 MIR92A1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEUROD2 NOP53 NUP153 NUP93 OGT PIN1 PPIA PRNP PSMD10 RAB3A RING1 SLC25A21-AS1 UBE3C VPS11 ZNF3	32 interacting genes: A2M ADRB2 AP1M2 APP CASK CHM CHML CHRM4 DMXL2 ECSIT EGFR GRSF1 KRTAP10-8 MAST1 MYO5A PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF REP15 RIMS1 RIMS2 RNF32 RPH3A RPH3AL SGSM2 SNCA SYTL4 SYTL5 VRTN
Entrez ID		2926	5864
HPRD ID		07276	01535
Ensembl ID		ENSG00000132463	ENSG00000105649
Uniprot IDs		Q12849	A0A024R7I7 P20336
PDB IDs		2LMI 4QU6 4QU7
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA 3'-UTR Binding Negative Regulation Of Translation MRNA Destabilization Negative Regulation Of Protein Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Motility Negative Regulation Of Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Regulation Of MRNA Stability Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of RNA Stability Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Angiogenesis Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development	Small GTPase Binding Vesicle-mediated Transport Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Intracellular Protein Localization Rab-protein Geranylgeranyltransferase Complex Synaptic Vesicle Priming Regulation Of Exocytosis Protein Geranylgeranylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Synapse Intracellular Protein Transport Protein Prenylation Secretion By Cell Neurexin Family Protein Binding Exocytosis Modulation Of Excitatory Postsynaptic Potential Cytoplasmic Vesicle Secretion Regulation Of Regulated Secretory Pathway Synaptic Vesicle Positive Regulation Of Vesicle Fusion Neuronal Dense Core Vesicle Signal Release Positive Regulation Of Exocytosis Astrocyte Activation Involved In Immune Response Rab Geranylgeranyltransferase Activity Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Neurotransmitter Transport Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Neurotransmitter Secretion Regulation Of Nervous System Process Regulation Of Secretion By Cell Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential Maintenance Of Presynaptic Active Zone Structure Synapse Organization Regulation Of Synaptic Vesicle Exocytosis Presynaptic Membrane Cellular Response To Amyloid-beta
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