TDP1 and TOP1

Number of citations of the paper that reports this interaction (PMID 12618186)
27

Data Source:
HPRD (in vitro)

		TDP1	TOP1
Gene Name		tyrosyl-DNA phosphodiesterase 1	topoisomerase (DNA) I
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding Exonuclease Activity Protein Binding 3'-tyrosyl-DNA Phosphodiesterase Activity	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug
Pathways		Nonhomologous End-joining (NHEJ) Processing of DNA ends prior to end rejoining Double-Strand Break Repair
Drugs			Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Diseases
GWAS			Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-Protein Interactions		2 interactors: LIG3 TOP1	55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I
Entrez ID		55775	7150
HPRD ID		06226	00535
Ensembl ID		ENSG00000042088	ENSG00000198900
Uniprot IDs		B3KN41 E7EPD8 Q9NUW8	P11387
PDB IDs		1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0	1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?		DNA Replication Base-excision Repair, DNA Ligation Otolith Morphogenesis Cell Division Lagging Strand Elongation Otolith Development Mitochondrial DNA Repair DNA Ligation Involved In DNA Repair DNA Ligation Embryonic Cleavage Mitochondrial DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination DNA Metabolic Process Embryo Development DNA Strand Elongation Involved In DNA Replication Mitochondrial Genome Maintenance DNA Strand Elongation DNA Topological Change Base-excision Repair Regulation Of DNA Recombination Circadian Regulation Of Gene Expression Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Inner Ear Morphogenesis DNA-dependent DNA Replication DNA Biosynthetic Process Ear Morphogenesis Double-strand Break Repair Circadian Rhythm	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated
Tagcloud ?		actually adducts ala albeit asn attacks bulky catalytically catalyze chemotherapeutics covalent gln h182a h432n h432r hisgab hisnuc hisnucala hisnucphe histidines histidyl nucleophile nucleophilic phosphodiesterase reportedly resolves scan1 top1 tyrosyl	anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts
Tagcloud (Difference) ?		actually adducts ala albeit asn attacks bulky catalyze chemotherapeutics covalent gln h182a h432n h432r hisgab hisnuc hisnucala hisnucphe histidines histidyl nucleophile nucleophilic phosphodiesterase reportedly resolves scan1 tyrosyl	anucleate complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts
Tagcloud (Intersection) ?		catalytically top1