TDP1 and LIG3

Number of citations of the paper that reports this interaction (PMID 15744309)
98

Data Source:
HPRD (two hybrid)

		TDP1	LIG3
Gene Name		tyrosyl-DNA phosphodiesterase 1	ligase III, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding Exonuclease Activity Protein Binding 3'-tyrosyl-DNA Phosphodiesterase Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Ligation Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Mitochondrion Organization Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Recombination Cell Division DNA Biosynthetic Process
Pathways		Nonhomologous End-joining (NHEJ) Processing of DNA ends prior to end rejoining Double-Strand Break Repair	Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs			Bleomycin
Diseases
GWAS			QT interval ( 19305408)
Protein-Protein Interactions		2 interactors: LIG3 TOP1	9 interactors: APP JTB NEIL1 PARP1 PNKP TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		55775	3980
HPRD ID		06226	02966
Ensembl ID		ENSG00000042088	ENSG00000005156
Uniprot IDs		B3KN41 E7EPD8 Q9NUW8	E5KLB5 E5KLB6 P49916
PDB IDs		1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
Enriched GO Terms of Interacting Partners?		DNA Replication Base-excision Repair, DNA Ligation Otolith Morphogenesis Cell Division Lagging Strand Elongation Otolith Development Mitochondrial DNA Repair DNA Ligation Involved In DNA Repair DNA Ligation Embryonic Cleavage Mitochondrial DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination DNA Metabolic Process Embryo Development DNA Strand Elongation Involved In DNA Replication Mitochondrial Genome Maintenance DNA Strand Elongation DNA Topological Change Base-excision Repair Regulation Of DNA Recombination Circadian Regulation Of Gene Expression Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Inner Ear Morphogenesis DNA-dependent DNA Replication DNA Biosynthetic Process Ear Morphogenesis Double-strand Break Repair Circadian Rhythm	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Hyperosmotic Salinity Response Cellular Response To Stress Double-strand Break Repair Cellular Response To X-ray Base-excision Repair Response To Stress Telomere Maintenance Establishment Of Integrated Proviral Latency DNA Damage Response, Detection Of DNA Damage Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Cellular Response To Salt Stress Single Strand Break Repair Response To Oxidative Stress Nucleobase-containing Compound Metabolic Process Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Cellular Nitrogen Compound Metabolic Process Hyperosmotic Response Cellular Response To Osmotic Stress Response To X-ray Nitrogen Compound Metabolic Process Response To Salt Stress Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Response To Ionizing Radiation Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Type I Interferon Production Response To Abiotic Stimulus Response To Osmotic Stress Negative Regulation Of Cellular Metabolic Process Nucleotide-excision Repair Regulation Of Type I Interferon Production Synaptic Growth At Neuromuscular Junction Negative Regulation Of Nuclease Activity Polynucleotide 3' Dephosphorylation Homeostatic Process Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Protein Poly-ADP-ribosylation DNA Catabolic Process Cellular Response To Radiation Response To Stimulus
Tagcloud ?		actually adducts ala albeit asn attacks bulky catalytically catalyze chemotherapeutics covalent gln h182a h432n h432r hisgab hisnuc hisnucala hisnucphe histidines histidyl nucleophile nucleophilic phosphodiesterase reportedly resolves scan1 top1 tyrosyl	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		actually adducts ala albeit asn attacks bulky catalytically catalyze chemotherapeutics covalent gln h182a h432n h432r hisgab hisnuc hisnucala hisnucphe histidines histidyl nucleophile nucleophilic phosphodiesterase reportedly resolves scan1 top1 tyrosyl	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?