TDP1

Description		tyrosyl-DNA phosphodiesterase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding Nuclease Activity Exonuclease Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity 3'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair DNA Damage Response
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Interacting Genes		3 interacting genes: LIG3 TOP1 UBC
Entrez ID		55775
HPRD ID		06226
Ensembl ID		ENSG00000042088
Uniprot IDs		B3KN41 G3V2F4 Q9NUW8
PDB IDs		1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0 5NW9 5NWA 6DHU 6DIE 6DIH 6DIM 6DJD 6DJE 6DJF 6DJG 6DJH 6DJI 6DJJ 6MJ5 6MYZ 6MZ0 6N0D 6N0N 6N0O 6N0R 6N17 6N19 6W4R 6W7J 6W7K 6W7L 7UFY 7UFZ 8CVQ 8CW2 8UV1 8UZV 8UZZ 8V0B 8V0C 9B3B
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Mitochondrial DNA Replication DNA Ligase III-XRCC1 Complex DNA Replication Regulation Of Mitochondrial DNA Replication DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Ligase Activity Dense Fibrillar Component DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Regulation Of Mitochondrial DNA Metabolic Process Cellular Response To Luteinizing Hormone Stimulus Mitochondrial DNA Repair DNA Topoisomerase Activity Response To Luteinizing Hormone Supercoiled DNA Binding Double-strand Break Repair Via Alternative Nonhomologous End Joining Embryonic Cleavage DNA Topological Change Negative Regulation Of DNA-templated DNA Replication Cell Division DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Protein Tag Activity DNA Binding, Bending V(D)J Recombination DNA Strand Elongation Mitochondrial DNA Metabolic Process Cellular Response To Gonadotropin Stimulus DNA Conformation Change RRNA Transcription Negative Regulation Of DNA Replication Response To Gonadotropin DNA Metabolic Process Nuclear Chromosome Base-excision Repair Somatic Cell DNA Recombination Nucleobase-containing Compound Biosynthetic Process Peptidyl-serine Phosphorylation Protein-DNA Complex Male Germ Cell Nucleus Response To Gamma Radiation Animal Organ Regeneration Double-strand Break Repair Via Nonhomologous End Joining Circadian Regulation Of Gene Expression Nucleoplasm Endocytic Vesicle Membrane
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