TDP1

Gene Name		tyrosyl-DNA phosphodiesterase 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding Exonuclease Activity Protein Binding 3'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Nonhomologous End-joining (NHEJ) Processing of DNA ends prior to end rejoining Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: LIG3 TOP1
Entrez ID		55775
HPRD ID		06226
Ensembl ID		ENSG00000042088
Uniprot IDs		B3KN41 E7EPD8 Q9NUW8
PDB IDs		1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0
Enriched GO Terms of Interacting Partners?		DNA Replication Base-excision Repair, DNA Ligation Otolith Morphogenesis Cell Division Lagging Strand Elongation Otolith Development Mitochondrial DNA Repair DNA Ligation Involved In DNA Repair DNA Ligation Embryonic Cleavage Mitochondrial DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Recombination DNA Metabolic Process Embryo Development DNA Strand Elongation Involved In DNA Replication Mitochondrial Genome Maintenance DNA Strand Elongation DNA Topological Change Base-excision Repair Regulation Of DNA Recombination Circadian Regulation Of Gene Expression Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Inner Ear Morphogenesis DNA-dependent DNA Replication DNA Biosynthetic Process Ear Morphogenesis Double-strand Break Repair Circadian Rhythm
Tagcloud ?		actually adducts ala albeit asn attacks bulky catalytically catalyze chemotherapeutics covalent gln h182a h432n h432r hisgab hisnuc hisnucala hisnucphe histidines histidyl nucleophile nucleophilic phosphodiesterase reportedly resolves scan1 top1 tyrosyl