PRKAR2A and WASF1

Number of citations: 43 (PubMedID 10970852)
Data Source: BioGRID (pull down), HPRD (in vitro)

		PRKAR2A	WASF1
Name		protein kinase cAMP-dependent type II regulatory subunit alpha	WASP family member 1
Structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Lamellipodium SCAR Complex Dendrite Cytoplasm Protein-containing Complex Synapse Anchoring Junction Postsynapse
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Actin Binding Protein Binding Small GTPase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Arp2/3 Complex Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Receptor-mediated Endocytosis Mitochondrion Organization Rac Protein Signal Transduction Actin Cytoskeleton Organization Actin Filament Polymerization Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein-containing Complex Assembly Lamellipodium Morphogenesis Dendrite Extension Modification Of Postsynaptic Actin Cytoskeleton Dendritic Transport Of Mitochondrion Cellular Response To Brain-derived Neurotrophic Factor Stimulus Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		GEM-231	None
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Depressive symptom (depressed mood) (binary trait) ( 31530331 ) Depressive symptom (depressed mood) (ordinal trait) ( 31530331 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Lipoprotein (a) levels ( 33730874 ) Morning person ( 30696823 ) Resting heart rate ( 27798624 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	No GWAS studies recorded
Novel Interactors		9 novel interactors: APBB1 GABARAPL2 HYAL1 MSN P4HA2 RBM6 RPL29 TCAIM XCR1	1 novel interactors: MMS22L
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1	38 interacting genes: ABI1 ABI3 ABL1 ACTB ACTG1 ACTR2 BAD BRK1 CCDC196 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP EFHC1 FYN GNAI1 GRB2 HSF2BP IFT20 IL12A ING5 LMO2 MAPKAPK2 NCK1 NCK2 NCKAP1 NYAP2 OSTF1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRAF2 TRIP10
Entrez ID		5576	8936
HPRD ID		01484	05434
Ensembl ID		ENSG00000114302	ENSG00000112290
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	Q92558
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	3P8C 4N78 7USC 7USD 7USE
GO Terms Enriched among Interactors		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Actin Cytoskeleton Organization Actin Filament-based Process Cell Motility Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization SCAR Complex Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell Migration Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Regulation Of Cell Projection Organization Regulation Of Lamellipodium Organization Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Lamellipodium Assembly Ephrin Receptor Binding Positive Regulation Of Cell Projection Organization Cell Projection Assembly Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Lamellipodium Organization Signaling Adaptor Activity Positive Regulation Of Protein Polymerization Regulation Of Cell Projection Assembly Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Phosphotyrosine Residue Binding Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cellular Component Size Organelle Organization Ephrin Receptor Signaling Pathway