PRKAR2A and AKAP3

Number of citations of the paper that reports this interaction (PubMedID 10319321)
0

Data Source:
HPRD (two hybrid, in vitro)

		PRKAR2A	AKAP3
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	A-kinase anchoring protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Acrosomal Vesicle Nucleus Cytoplasm Cilium Cytoplasmic Vesicle Motile Cilium Sperm Fibrous Sheath Cell Projection Sperm Midpiece Sperm Principal Piece
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Binding Protein Kinase A Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Blastocyst Hatching Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Single Fertilization Acrosome Reaction Intracellular Protein Localization Flagellated Sperm Motility Establishment Of Protein Localization
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		GEM-231
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1	8 interacting genes: AKAP4 BRAP GNA13 PRKAR2A ROPN1 ROPN1B ROPN1L SPA17
Entrez ID		5576	10566
HPRD ID		01484	05256
Ensembl ID		ENSG00000114302	ENSG00000111254
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	O75969 V9HWD4
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Cilium Movement Motile Cilium Sperm Capacitation Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Microtubule-based Movement Cilium Sperm Fibrous Sheath CAMP-dependent Protein Kinase Complex Microtubule-based Process Developmental Process Involved In Reproduction Cell Maturation Sperm Principal Piece Developmental Maturation Reproductive Process Small GTPase-mediated Signal Transduction Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Cilium Organization Protein Localization To Cilium Rho Protein Signal Transduction Cytoplasm Cell Motility D5 Dopamine Receptor Binding Single Fertilization Male Gamete Generation Spermatogenesis Sperm End Piece Gamete Generation Cell Projection Fertilization Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho-activating G Protein-coupled Receptor Signaling Pathway CAMP-dependent Protein Kinase Regulator Activity Microtubule-based Transport CAMP-dependent Protein Kinase Inhibitor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nucleotide-activated Protein Kinase Complex Intracellular Signal Transduction Intracellular Signaling Cassette Radial Spoke Plasma Membrane Bounded Cell Projection Organization Protein Kinase A Catalytic Subunit Binding Sperm Head-tail Coupling Apparatus Guanyl Nucleotide Binding Acrosome Reaction Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sperm Flagellum Assembly
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