PRKAR2A and RUNX1T1

Number of citations of the paper that reports this interaction (PMID 11593431)
11

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PRKAR2A	RUNX1T1
Gene Name		protein kinase, cAMP-dependent, regulatory, type II, alpha	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome Ciliary Base	Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Renal Water Homeostasis Energy Reserve Metabolic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways		Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP2 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CFTR EZR MAP2 MYCBPAP NBEA PJA2 PPP1CB PRKX RAB32 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1	53 interactors: ABI3 ATN1 BCL6 BRCA1 C19orf57 CBFA2T3 CCDC36 CEP170P1 CPSF7 CREB3L1 DNMT1 EFHC2 EPS8 ETS1 GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HSP90AA1 ID1 ID3 KPNA1 KPNB1 LPXN LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 PCBD2 PRDM14 PRKAR2A SIN3A SPEN SPERT SPRY2 STX11 TAF9B TAL2 TCF12 TCF3 TCF4 TRIM42 UBQLN4 VDR WBP11 ZBTB16 ZMYM4 ZNF652
Entrez ID		5576	862
HPRD ID		01484	00590
Ensembl ID		ENSG00000114302	ENSG00000079102
Uniprot IDs		P13861 Q9BUB1	B2R6I9 Q06455
PDB IDs		2IZX 2KYG	1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase A Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Signaling Cellular Response To CAMP Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Communication Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Cellular Response To Stimulus Regulation Of Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transport Response To Stimulus Protein Localization Response To Purine-containing Compound Regulation Of Membrane Repolarization Regulation Of Signal Transduction Positive Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cation Channel Activity Cellular Response To Organic Cyclic Compound Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Positive Regulation Of Protein Kinase A Signaling Regulation Of Potassium Ion Transmembrane Transport Response To CAMP Regulation Of Membrane Potential Positive Regulation Of Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity SMAD Protein Complex Assembly Response To Organophosphorus Regulation Of Delayed Rectifier Potassium Channel Activity Sexual Reproduction Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Potassium Ion Transport Epithelial Tube Morphogenesis Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transport Action Potential Tube Morphogenesis Regulation Of CAMP Biosynthetic Process Regulation Of Cellular Process Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Negative Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Embryo Development Cellular Metabolic Process Organ Development Developmental Process Anatomical Structure Development System Development Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Differentiation Cellular Response To Organic Substance Rhythmic Process Organelle Organization Regulation Of Apoptotic Process
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	accumulated aml aml201 cbfb cebpa chimeric clarify comprehensively cooperative cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	accumulated aml aml201 cbfb cebpa chimeric clarify comprehensively cooperative cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations
Tagcloud (Intersection) ?