PRKAR2A and AKAP7

Number of citations of the paper that reports this interaction (PubMedID 12672969)
55

Data Source:
HPRD (in vitro, in vivo)

		PRKAR2A	AKAP7
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	A-kinase anchoring protein 7
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Protein-containing Complex Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Nucleotide Binding Protein Binding Protein Kinase Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Action Potential Monoatomic Ion Transport Intracellular Protein Localization Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Regulation Of Membrane Repolarization Cellular Response To CAMP Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		GEM-231
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hip circumference adjusted for BMI ( 34021172) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1	7 interacting genes: C8orf34 CEP76 PRKAR1A PRKAR2A ROPN1 ROPN1L SPA17
Entrez ID		5576	9465
HPRD ID		01484	16065
Ensembl ID		ENSG00000114302	ENSG00000118507
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	A0A804HI88 A0A9L9PYJ6 O43687 Q2TAJ5 Q6P4D3 Q9P0M2
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	4ZP3 5JJ2
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Protein Kinase A Catalytic Subunit Binding CAMP Binding Sperm Capacitation Cilium Movement Negative Regulation Of CAMP/PKA Signal Transduction Motile Cilium Plasma Membrane Raft Regulation Of CAMP/PKA Signal Transduction Ciliary Base Epithelial Cilium Movement Involved In Extracellular Fluid Movement Extracellular Transport Microtubule-based Movement Axoneme Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Cilium Movement Involved In Cell Motility Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Centrosome Cell Maturation Protein-containing Complex Sperm Fibrous Sheath Developmental Maturation Microtubule-based Process Microtubule-based Transport Protein Domain Specific Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Developmental Process Involved In Reproduction Cellular Response To Glucagon Stimulus Radial Spoke Negative Regulation Of Activated T Cell Proliferation Ubiquitin Protein Ligase Binding Sperm Head-tail Coupling Apparatus Response To Glucagon
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