PRKAR2A and ARFGEF2

Number of citations of the paper that reports this interaction (PubMedID 12571360)
44

Data Source:
HPRD (two hybrid, in vitro)

		PRKAR2A	ARFGEF2
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	ARF guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Golgi Membrane Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Axonemal Microtubule Membrane Dendrite Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Cell Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Vesicle-mediated Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Association of TriC/CCT with target proteins during biosynthesis
Drugs		GEM-231
Diseases			Periventricular nodular heterotopia (PVNH)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1	10 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 LCOR PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		5576	10564
HPRD ID		01484	09250
Ensembl ID		ENSG00000114302	ENSG00000124198
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	A0A7P0T7Z2 Q59FR3 Q86TH5 Q9Y6D5
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	3L8N 3SWV
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Cellular Response To Histamine Response To Histamine GABA-A Receptor Activity GABA-gated Chloride Ion Channel Activity GABA-A Receptor Complex Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane Synaptic Transmission, GABAergic Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Chloride Channel Complex CAMP-dependent Protein Kinase Regulator Activity Chloride Channel Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Inner Ear Receptor Cell Development Chloride Transmembrane Transport Regulation Of Postsynaptic Membrane Potential Protein Kinase A Catalytic Subunit Binding GABA-ergic Synapse Chloride Transport Inorganic Anion Transmembrane Transport Regulation Of Biological Quality Innervation CAMP Binding Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Inhibitory Synapse Assembly Negative Regulation Of CAMP/PKA Signal Transduction Monoatomic Ion Channel Activity Neuron Development Cochlea Development Plasma Membrane Raft Membrane Ciliary Base Transmembrane Signaling Receptor Activity Regulation Of CAMP/PKA Signal Transduction Postsynaptic Membrane Transmembrane Transport Circadian Sleep/wake Cycle, REM Sleep Prostaglandin-I Synthase Activity Inorganic Ion Transmembrane Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Trans-synaptic Signaling Synaptic Signaling Regulation Of Cytokinesis
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