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PRKAR2A and SEMG2
Number of citations of the paper that reports this interaction (PubMedID
12399526
)
0
Data Source:
HPRD
(in vitro, in vivo)
PRKAR2A
SEMG2
Description
protein kinase cAMP-dependent type II regulatory subunit alpha
semenogelin 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Focal Adhesion
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nucleotide-activated Protein Kinase Complex
Protein-containing Complex
Plasma Membrane Raft
Extracellular Exosome
Ciliary Base
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Nucleus
Extracellular Exosome
Molecular Function
Nucleotide Binding
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Protein Domain Specific Binding
CAMP Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
Protease Binding
Protein Binding
Zinc Ion Binding
Biological Process
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of CAMP/PKA Signal Transduction
Antibacterial Humoral Response
Sperm Capacitation
Coagulation
Positive Regulation Of Serine-type Endopeptidase Activity
Negative Regulation Of Flagellated Sperm Motility
Pathways
PKA activation
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
CREB1 phosphorylation through the activation of Adenylate Cyclase
Hedgehog 'off' state
ROBO receptors bind AKAP5
GPER1 signaling
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
Factors involved in megakaryocyte development and platelet production
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
GEM-231
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Depressive symptom (depressed mood) (binary trait) (
31530331
)
Depressive symptom (depressed mood) (ordinal trait) (
31530331
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Inflammatory bowel disease (
28067908
)
Lipoprotein (a) levels (
33730874
)
Morning person (
30696823
)
Resting heart rate (
27798624
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Asthma (
29273806
)
Bipolar disorder (
31043756
)
Malaria (
31844061
)
Interacting Genes
40 interacting genes:
AKAP1
AKAP10
AKAP11
AKAP12
AKAP13
AKAP14
AKAP3
AKAP4
AKAP5
AKAP6
AKAP7
AKAP8
AKAP9
ARFGEF2
CBFA2T3
CDK1
CFTR
EZR
FOS
IFNAR2
LRIF1
MAP2
MYCBPAP
NBEA
OGT
PJA2
PPP1CB
PRKACA
PRKX
RAB32
RACK1
RET
RUNX1T1
RYR2
SCTR
SEMG2
SMAD3
SMAD4
WASF1
WEE2-AS1
8 interacting genes:
KLK2
KLK3
PRKAR2A
PRKCA
PTPRF
SEMG1
SERPINA5
TGM1
Entrez ID
5576
6407
HPRD ID
01484
01642
Ensembl ID
ENSG00000114302
ENSG00000124157
Uniprot IDs
A0A024R2W3
A0A0S2Z472
A0A9L9PY56
A8KAH7
P13861
Q02383
PDB IDs
2IZX
2KYG
4ZP3
5H78
5XBY
8S8O
Enriched GO Terms of Interacting Partners
?
Protein Kinase A Regulatory Subunit Binding
Protein Kinase A Binding
Regulation Of Protein Kinase A Signaling
CAMP-dependent Protein Kinase Complex
Cellular Response To Oxygen-containing Compound
Positive Regulation Of Intracellular Transport
Response To Purine-containing Compound
Response To CAMP
Positive Regulation Of Transport
Positive Regulation Of Protein Localization
Cellular Response To CAMP
Regulation Of Protein Catabolic Process
Cellular Response To Glucose Stimulus
Signal Transduction
Regulation Of Cellular Localization
Cellular Response To Carbohydrate Stimulus
Intracellular Signaling Cassette
Intracellular Signal Transduction
Adenylate Cyclase Binding
Intracellular Glucose Homeostasis
Positive Regulation Of Protein Transport
Regulation Of Protein Localization
Protein Kinase A Catalytic Subunit Binding
Regulation Of Intracellular Transport
Molecular Adaptor Activity
GABA Receptor Binding
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Sperm Capacitation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Dendritic Branch
Response To Glucose
Positive Regulation Of Establishment Of Protein Localization
Protein Kinase Binding
Response To Monosaccharide
Positive Regulation Of Protein Kinase A Signaling
SMAD Protein Signal Transduction
MAPK Cascade
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Calcium Channel Complex
R-SMAD Binding
Multicellular Organismal-level Water Homeostasis
Membrane To Membrane Docking
Regulation Of Multicellular Organismal Process
Regulation Of Transport
Response To Carbohydrate
Intracellular Chemical Homeostasis
Negative Regulation Of Cell Growth
CAMP-dependent Protein Kinase Activity
Positive Regulation Of Intracellular Protein Transport
Cellular Response To Growth Factor Stimulus
Extracellular Exosome
Protein-containing Complex
Zymogen Activation
Regulation Of Systemic Arterial Blood Pressure
Protein C Inhibitor-coagulation Factor V Complex
Protein C Inhibitor-TMPRSS7 Complex
Protein C Inhibitor-PLAU Complex
Protein C Inhibitor-TMPRSS11E Complex
Protein C Inhibitor-coagulation Factor Xa Complex
Protein C Inhibitor-KLK3 Complex
Protein C Inhibitor-plasma Kallikrein Complex
Protein C Inhibitor-thrombin Complex
Protein C Inhibitor-coagulation Factor XI Complex
Protein C Inhibitor-PLAT Complex
Chondroitin Sulfate Proteoglycan Binding
Serine-type Peptidase Activity
Secretory Granule
Platelet Dense Tubular Network
Seminal Clot Liquefaction
Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity
Positive Regulation Of Dense Core Granule Biogenesis
Positive Regulation Of Angiotensin-activated Signaling Pathway
Histone H3T6 Kinase Activity
Alphav-beta3 Integrin-PKCalpha Complex
Negative Regulation Of Flagellated Sperm Motility
Positive Regulation Of Serine-type Endopeptidase Activity
Cell Envelope Organization
Positive Regulation Of Antibacterial Peptide Production
Acrosin Binding
Protein Kinase C Signaling
Negative Regulation Of Receptor Binding
Insemination
Serine-type Endopeptidase Activity
Heparin Binding
Regulation Of Angiotensin-activated Signaling Pathway
Regulation Of Blood Pressure
Regulation Of Antibacterial Peptide Production
Positive Regulation Of Antimicrobial Peptide Production
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Extracellular Space
Protein Processing
Positive Regulation Of Antimicrobial Humoral Response
CAMP-dependent Protein Kinase Regulator Activity
Desmosome Assembly
Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway
Protein-glutamine Gamma-glutamyltransferase Activity
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Endopeptidase Activity
Regulation Of Antimicrobial Humoral Response
Protein Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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