PRKAR2A and AKAP13

Number of citations of the paper that reports this interaction (PubMedID 12672969)
55

Data Source:
HPRD (in vitro, in vivo)

		PRKAR2A	AKAP13
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	A-kinase anchoring protein 13
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Nucleus Cytoplasm Cytosol Cell Cortex Actin Cytoskeleton Membrane Cortical Actin Cytoskeleton
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	MAP-kinase Scaffold Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	MAPK Cascade G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Adrenergic Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		GEM-231
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	A body shape index ( 34021172) Birth weight ( 31043758) Central corneal thickness ( 20719862 32528159 31798171 29760442) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) High myopia ( 32428537) Idiopathic pulmonary fibrosis ( 31710517 29066090) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) Platelet count ( 32888494) Platelet distribution width ( 32888494) Post-bronchodilator lung function in asthma (FEV1/FVC) ( 32989782) Psoriasis ( 25939698) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1	21 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ
Entrez ID		5576	11214
HPRD ID		01484	05253
Ensembl ID		ENSG00000114302	ENSG00000170776
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	A8MYJ1 B0AZU4 Q12802
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	2DRN 2LG1 4D0N 4D0O 6BCA
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Intracellular Signal Transduction Signal Transduction Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Receptor Activity Protein Domain Specific Binding Nuclear Steroid Receptor Activity Intracellular Signaling Cassette Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Phosphoserine Residue Binding Protein Sequestering Activity Cellular Response To Oxygen-containing Compound Focal Adhesion Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Rho Protein Signal Transduction Cellular Response To Starvation Negative Regulation Of MiRNA Transcription Regulation Of Cell Communication Regulation Of Signaling Response To Starvation Response To Norepinephrine Cellular Response To Norepinephrine Stimulus Nuclear Estrogen Receptor Activity Cellular Response To Nutrient Levels Regulation Of Nucleocytoplasmic Transport Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Protein Localization To Nucleus Cytosol Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Localization To Nucleus Regulation Of System Process Cellular Response To Amino Acid Starvation Positive Regulation Of Transcription By RNA Polymerase II Response To Amino Acid Starvation Regulation Of Biological Quality Estrogen Response Element Binding G Protein Activity G Protein-coupled Receptor Binding Enzyme Binding Protein Targeting Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Innate Immune Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
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