PRKAR2A and HYAL1

Data Source: HiPPIP (Novel)

		PRKAR2A	HYAL1
Name		protein kinase cAMP-dependent type II regulatory subunit alpha	hyaluronidase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Extracellular Region Extracellular Space Lysosome Cytoplasmic Vesicle Hyaluranon Cable Lysosomal Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Virus Receptor Activity Hyalurononglucosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Chondroitin Hydrolase Activity
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Response To Reactive Oxygen Species Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Inflammatory Response Response To Virus Chondroitin Sulfate Proteoglycan Catabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Response To Antibiotic Cartilage Development Embryonic Skeletal Joint Morphogenesis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To PH Cellular Response To UV-B Positive Regulation Of Hyaluranon Cable Assembly
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	CS/DS degradation Hyaluronan degradation MPS IX - Natowicz syndrome (Hyaluronan metabolism) MPS IX - Natowicz syndrome (CS/DS degradation)
Drugs		GEM-231	None
Diseases		None	Mucopolysaccharidosis type IX (MPS9); Hyaluronidase deficiency
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Depressive symptom (depressed mood) (binary trait) ( 31530331 ) Depressive symptom (depressed mood) (ordinal trait) ( 31530331 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density ( 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Lipoprotein (a) levels ( 33730874 ) Morning person ( 30696823 ) Resting heart rate ( 27798624 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Depressive symptom (appetite changes) (binary trait) ( 31530331 ) Depressive symptoms (binary sum-score) ( 31530331 ) Depressive symptoms (sum-score) ( 31530331 ) Sleep duration (short sleep) ( 30846698 )
Novel Interactors		9 novel interactors: APBB1 GABARAPL2 HYAL1 MSN P4HA2 RBM6 RPL29 TCAIM XCR1	1 novel interactors: PRKAR2A
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1	1 interacting genes: COL2A1
Entrez ID		5576	3373
HPRD ID		01484	06146
Ensembl ID		ENSG00000114302	ENSG00000114378
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	A0A024R2X3 A0A0S2Z3Q0 B3KUI5 Q12794
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	2PE4
GO Terms Enriched among Interactors		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Fibrillar Collagen Trimer Collagen Type XI Trimer Otic Vesicle Development Collagen Type II Trimer Notochord Development Platelet-derived Growth Factor Binding MHC Class II Protein Binding Limb Bud Formation Anterior Head Development Nucleotide-activated Protein Kinase Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Embryonic Skeletal Joint Morphogenesis Proteoglycan Binding Protein Kinase A Catalytic Subunit Binding Cartilage Condensation Cartilage Development Involved In Endochondral Bone Morphogenesis CAMP Binding Cell Aggregation Head Development Negative Regulation Of CAMP/PKA Signal Transduction Endochondral Ossification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extracellular Matrix Structural Constituent Conferring Tensile Strength Cellular Response To BMP Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Plasma Membrane Raft Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ciliary Base Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Signal Transduction Heart Morphogenesis Inner Ear Development Collagen Fibril Organization Chondrocyte Differentiation Inner Ear Morphogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Bone Development Collagen Trimer Roof Of Mouth Development Embryonic Skeletal System Morphogenesis Proteoglycan Metabolic Process Basement Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Limb Morphogenesis Cartilage Development Skeletal System Morphogenesis Extracellular Matrix Structural Constituent