PRKAR2A and AKAP1

Number of citations of the paper that reports this interaction (PubMedID 9065479)
0

Data Source:
HPRD (in vitro)

		PRKAR2A	AKAP1
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	A-kinase anchoring protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Nucleic Acid Binding RNA Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Apoptotic Process Antiviral Innate Immune Response
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Mitochondrial calcium ion transport Factors involved in megakaryocyte development and platelet production
Drugs		GEM-231
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blond vs. brown/black hair color ( 30531825) Crohn's disease ( 26192919) Freckles ( 29895819) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 27182965)
Interacting Genes		40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1	12 interacting genes: AMY1A CAV1 CFAP91 DYSF MYCBP PPP1CA PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPN21 RNF10
Entrez ID		5576	8165
HPRD ID		01484	03905
Ensembl ID		ENSG00000114302	ENSG00000121057
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	A0A140VK05 B4DN86 Q92667
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Ciliary Base Protein Kinase A Catalytic Subunit Binding CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Glutamatergic Synapse Axoneme Plasma Membrane Raft Negative Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Domain Specific Binding Postsynapse Cellular Response To Glucagon Stimulus Ubiquitin Protein Ligase Binding Response To Glucagon Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Mesoderm Formation Multivesicular Body Regulation Of Vesicle-mediated Transport Positive Regulation Of Glucose Metabolic Process Regulation Of System Process Inward Rectifier Potassium Channel Inhibitor Activity Monocyte Activation Involved In Immune Response Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Formation Of Primary Germ Layer Regulation Of Carbohydrate Catabolic Process Centrosome Negative Regulation Of Endocytosis Alpha-amylase Activity Caveolar Macromolecular Signaling Complex Regulation Of Cell Communication Response To Peptide Hormone Regulation Of Signaling Regulation Of Endocytosis RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Response To Antipsychotic Drug Radial Spoke Stalk Neuromuscular Junction Regulation Of Cardiac Muscle Contraction Regulation Of Small Molecule Metabolic Process
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