RUNX1T1 and HDAC8

Number of citations of the paper that reports this interaction (PMID 11533236)
75

Data Source:
HPRD (in vivo)

		RUNX1T1	HDAC8
Gene Name		runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	histone deacetylase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix	Histone Deacetylase Complex Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding Metal Ion Binding	Histone Deacetylase Activity Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Sister Chromatid Cohesion Chromatin Modification Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Cohesin Localization To Chromatin
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Chromatin organization HDACs deacetylate histones Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs			Vorinostat 4-Dimethylamino-N-(6-Hydroxycarbamoyethyl)Benzamide-N-Hydroxy-7-(4-Dimethyla Minobenzoyl)Aminoheptanamide N-Hydroxy-4-(Methyl{[5-(2-Pyridinyl)-2-Thienyl]Sulfonyl}Amino)Benzamide 7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide (2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide 5-(4-METHYL-BENZOYLAMINO)-BIPHENYL-3,4\'-DICARBOXYLIC ACID 3-DIMETHYLAMIDE-4\'-HYDROXYAMIDE 7-AMINO-4-METHYL-CHROMEN-2-ONE
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ABI3 ATN1 BCL6 BRCA1 C19orf57 CBFA2T3 CCDC36 CEP170P1 CPSF7 CREB3L1 DNMT1 EFHC2 EPS8 ETS1 GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HSP90AA1 ID1 ID3 KPNA1 KPNB1 LPXN LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 PCBD2 PRDM14 PRKAR2A SIN3A SPEN SPERT SPRY2 STX11 TAF9B TAL2 TCF12 TCF3 TCF4 TRIM42 UBQLN4 VDR WBP11 ZBTB16 ZMYM4 ZNF652	9 interactors: ESRRA HIST1H3A HIST1H4A HIST3H3 HIST4H4 MDC1 PRKACA RTN1 RUNX1T1
Entrez ID		862	55869
HPRD ID		00590	02227
Ensembl ID		ENSG00000079102	ENSG00000147099
Uniprot IDs		B2R6I9 Q06455	Q9BY41
PDB IDs		1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL	1T64 1T67 1T69 1VKG 1W22 2V5W 2V5X 3EW8 3EWF 3EZP 3EZT 3F06 3F07 3F0R 3MZ3 3MZ4 3MZ6 3MZ7 3RQD 3SFF 3SFH
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Negative Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Embryo Development Cellular Metabolic Process Organ Development Developmental Process Anatomical Structure Development System Development Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Differentiation Cellular Response To Organic Substance Rhythmic Process Organelle Organization Regulation Of Apoptotic Process	DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing Regulation Of Myeloid Cell Differentiation Histone H4-K20 Demethylation DNA Methylation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Telomere Maintenance DNA Modification Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Silencing Nucleosome Assembly Chromatin Assembly Chromosome Organization Nucleosome Organization DNA Metabolic Process Chromatin Assembly Or Disassembly Negative Regulation Of Transcription, DNA-templated Regulation Of Megakaryocyte Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging CENP-A Containing Nucleosome Assembly Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Chromatin Organization Protein Demethylation Mitotic Cell Cycle DNA Conformation Change Centromere Complex Assembly Nucleobase-containing Compound Metabolic Process Demethylation ATP-dependent Chromatin Remodeling Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Modification Positive Regulation Of Dense Core Granule Biogenesis Methylation Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		accumulated aml aml201 cbfb cebpa chimeric clarify comprehensively cooperative cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations	activator acylthiourea anticancer calorimetric conformed cooperative deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein
Tagcloud (Difference) ?		accumulated aml aml201 cbfb cebpa chimeric clarify comprehensively cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations	activator acylthiourea anticancer calorimetric conformed deacetylase derivative detailed discriminatory encoded feature insight isothermal isozyme kinetic kinetics malignancy mechanistic modeling neuroblastoma served sh steady sy5y thermodynamics titration tm wherein
Tagcloud (Intersection) ?		cooperative