RUNX1T1 and VPS52

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RUNX1T1	VPS52
Description		RUNX1 partner transcriptional co-repressor 1	VPS52 subunit of GARP complex
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix	GARP Complex Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Presynapse Postsynapse EARP Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Protein Binding Syntaxin Binding
	Biological Process	DNA-templated Transcription Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription	Protein Targeting Golgi To Vacuole Transport Lysosomal Transport Ectodermal Cell Differentiation Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi Embryonic Ectodermal Digestive Tract Development Vesicle-mediated Cholesterol Transport
Pathways			Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases		Acute myeloid leukemia (AML)
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Number of sexual partners ( 30643258) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Plasma anti-thyroglobulin levels ( 29678681) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971)
Interacting Genes		99 interacting genes: ABI3 ADAMTSL4 ARHGAP9 ATN1 BCL6 BIRC2 BRCA1 BRME1 CBFA2T3 CBY2 CCDC197 CDC23 CDR2 CEP170P1 CEP83 COG6 CPSF7 CREB3L1 DEUP1 DNMT1 EFHC2 EPS8 ETS1 FAM136A FAM9A GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HOXB2 HSP90AA1 ID1 ID3 IHO1 KIAA0408 KIFC3 KPNA1 KPNB1 KRT23 KRT27 KRT33B KRT35 KRTAP13-3 KRTAP19-6 KRTAP6-2 KRTAP6-3 LHX3 LPXN LZTS1 LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 OIP5 PCBD2 PIAS2 PLSCR3 PRDM16 PRDM6 PRKAR1B PRKAR2A RAD54L2 REL RNF4 RTN4IP1 SH3RF1 SIN3A SORBS3 SPEN SPRY2 STX11 SYCE1 TAF9B TAL2 TCF12 TCF3 TCF4 TEKT1 TFIP11 TRIM42 TRIM54 UBQLN4 VDR VPS52 WBP11 XIAP ZBTB16 ZFP36 ZFP90 ZMAT1 ZMYM4 ZNF343 ZNF652 ZNF655	101 interacting genes: AAMP AIRIM ARNT2 ATP6V1D BYSL C1orf216 CABP5 CACNA1A CATSPERT CCDC102B CCDC13 CCDC146 CCDC185 CCDC187 CCDC33 CCDC57 CCHCR1 CDC20B CDC5L CDK18 CEP19 CFAP206 CWF19L2 DCX DDX6 DNAJC11 DTNB EPM2AIP1 FAM110A FAM161A FAM161B FAM184A FAM50B GEM GFM2 GOLGA1 GORASP2 GPKOW HAUS1 HDAC4 HEATR1 HGS HOXB5 JAKMIP2 KANK2 KIAA1217 KIF5B KIF9 KIFC3 KLC3 KLHL42 LMO4 LNX1 MAGEL2 MAPK3 METTL13 MFAP1 MRPL1 MRPL11 NDC80 NFKBIB NOP2 NR2C2AP OTUD6A PIMREG PKN3 PPP1R18 PRKAA1 PRKAA2 RAB4A RAB4B RABEP2 RUNX1T1 SCNM1 SH2D4A SMARCE1 STX11 TAB2 TBC1D1 TBC1D22B TCEANC TCP11L1 TEAD4 THAP11 TPM3 TRAF4 TRAF6 TSSK3 TSTD2 TXLNB TXN2 USP2 VEZF1 VPS28 VPS53 WASHC3 WTAP ZC2HC1C ZMAT2 ZNF417 ZNF587
Entrez ID		862	6293
HPRD ID		00590	09142
Ensembl ID		ENSG00000079102	ENSG00000223501
Uniprot IDs		A0A0A0MSU1 B2R6I9 E5RH72 Q06455 W8FW32	A0A1U9X8S4 B3KMF7 B4DS44 Q4VXZ2 Q8N1B4
PDB IDs		1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL
Enriched GO Terms of Interacting Partners?		Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Androgen Receptor Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Intermediate Filament Histone Deacetylase Complex Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death Zinc Ion Binding Transcription Corepressor Binding Chromatin Positive Regulation Of Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process E-box Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Epigenetic Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Protein Binding Cytoskeleton Organelle Assembly Centrosome Microtubule Binding Microtubule-based Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Organelle Organization Organelle Disassembly Ciliary Basal Body Kinesin Complex Protein Localization To Lipid Droplet Protein Localization To Vacuole Microtubule Cytoskeleton Organization Protein Localization To Lysosome Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Insulin-responsive Compartment Centriole
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