RUNX1T1 and KIAA0408

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RUNX1T1	KIAA0408
Description		RUNX1 partner transcriptional co-repressor 1	KIAA0408
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Matrix
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Protein Binding
	Biological Process	DNA-templated Transcription Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases		Acute myeloid leukemia (AML)
GWAS		Adult body size ( 32376654) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Number of sexual partners ( 30643258) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Plasma anti-thyroglobulin levels ( 29678681) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)	Asthma ( 31959851) Hip index ( 34021172) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		99 interacting genes: ABI3 ADAMTSL4 ARHGAP9 ATN1 BCL6 BIRC2 BRCA1 BRME1 CBFA2T3 CBY2 CCDC197 CDC23 CDR2 CEP170P1 CEP83 COG6 CPSF7 CREB3L1 DEUP1 DNMT1 EFHC2 EPS8 ETS1 FAM136A FAM9A GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HOXB2 HSP90AA1 ID1 ID3 IHO1 KIAA0408 KIFC3 KPNA1 KPNB1 KRT23 KRT27 KRT33B KRT35 KRTAP13-3 KRTAP19-6 KRTAP6-2 KRTAP6-3 LHX3 LPXN LZTS1 LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 OIP5 PCBD2 PIAS2 PLSCR3 PRDM16 PRDM6 PRKAR1B PRKAR2A RAD54L2 REL RNF4 RTN4IP1 SH3RF1 SIN3A SORBS3 SPEN SPRY2 STX11 SYCE1 TAF9B TAL2 TCF12 TCF3 TCF4 TEKT1 TFIP11 TRIM42 TRIM54 UBQLN4 VDR VPS52 WBP11 XIAP ZBTB16 ZFP36 ZFP90 ZMAT1 ZMYM4 ZNF343 ZNF652 ZNF655	42 interacting genes: ABI1 ABI3 AP2B1 BEGAIN CARD9 CBY2 CCDC57 CCDC85B CEP72 DCTN1 DTNBP1 FRS3 GFAP GRB2 HOOK2 HSF2BP KDM1A KRT15 MAGEA11 MDFI MYO15B NCK2 NDOR1 PFDN1 PHF1 PIK3R3 POLR3C PRMT6 RUNX1T1 SFN SORBS3 TEX11 TLE1 TRAF2 TRIM37 TRIM55 TRIM63 UBASH3A VIM XRCC6 YWHAG ZDHHC17
Entrez ID		862	9729
HPRD ID		00590	17187
Ensembl ID		ENSG00000079102	ENSG00000189367
Uniprot IDs		A0A0A0MSU1 B2R6I9 E5RH72 Q06455 W8FW32	Q6ZU52
PDB IDs		1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL
Enriched GO Terms of Interacting Partners?		Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Androgen Receptor Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Intermediate Filament Histone Deacetylase Complex Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death Zinc Ion Binding Transcription Corepressor Binding Chromatin Positive Regulation Of Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process E-box Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Epigenetic Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Identical Protein Binding Signaling Adaptor Activity Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Cytoskeleton Organization Protein Kinase C Inhibitor Activity Cytoplasm Scaffold Protein Binding IRE1-TRAF2-ASK1 Complex Regulation Of Cellular Component Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Vesicle Membrane Structural Constituent Of Cytoskeleton Regulation Of Metabolic Process Innate Immune Response Protein Sequestering Activity Actin-based Cell Projection Negative Regulation Of Metabolic Process Phosphotyrosine Residue Binding Organelle Organization Intermediate Filament Cytoskeleton Negative Regulation Of Macromolecule Metabolic Process Bergmann Glial Cell Differentiation Regulation Of Protein Kinase Activity Regulation Of Macromolecule Metabolic Process SCAR Complex Cellular Response To Stress Protein Binding Regulation Of Kinase Activity Cell Leading Edge Defense Response To Symbiont Regulation Of JNK Cascade Defense Response To Other Organism Glial Cell Development ESC/E(Z) Complex Negative Regulation Of Macromolecule Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cytoskeleton Regulation Of Gene Expression Cellular Response To Ionizing Radiation Intermediate Filament Organization Cellular Response To Reactive Nitrogen Species Negative Regulation Of Biosynthetic Process Positive Regulation Of Supramolecular Fiber Organization Astrocyte Development Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Anoikis
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