SLF2 and TRIM14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLF2	TRIM14
Description		SMC5/6 complex localization factor 2	tripartite motif containing 14
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm PML Body Smc5-Smc6 Complex Site Of Double-strand Break	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding Molecular Adaptor Activity Ubiquitin Protein Ligase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair	Immune System Process Inflammatory Response Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of DNA-templated Transcription Protein K48-linked Deubiquitination
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)	Multiple sclerosis ( 31604244)
Interacting Genes		7 interacting genes: CALM1 CBS OPTN PSMA1 SFMBT2 SMC6 TRIM14	85 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 DHX58 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		55719	9830
HPRD ID		12581	05948
Ensembl ID		ENSG00000119906	ENSG00000106785
Uniprot IDs		Q8IX21	Q14142
PDB IDs		7T5P	6JBM
Enriched GO Terms of Interacting Partners?		Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Nucleus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Biosynthetic Process Cysteine Biosynthetic Process From Serine L-serine Catabolic Process Transsulfuration Cysteine Biosynthetic Process Via Cystathionine Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Cystathionine Beta-synthase Activity Nitric Oxide Binding Carbon Monoxide Binding Negative Regulation Of Receptor Recycling Type 2 Mitophagy DNA Secondary Structure Binding Interchromatin Granule Chromosomal Region Sex Chromosome Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking DNA Protection Modified Amino Acid Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Proteasome Core Complex, Alpha-subunit Complex Positive Regulation Of Xenophagy Smc5-Smc6 Complex Regulation Of Nitric Oxide Mediated Signal Transduction Response To Folic Acid Golgi Ribbon Formation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process
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