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SLF2 and OPTN
Number of citations of the paper that reports this interaction (PubMedID
20195357
)
57
Data Source:
BioGRID
(pull down)
SLF2
OPTN
Description
SMC5/6 complex localization factor 2
optineurin
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
PML Body
Smc5-Smc6 Complex
Site Of Double-strand Break
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Autophagosome
Golgi Apparatus
Trans-Golgi Network
Cytosol
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Recycling Endosome
Recycling Endosome Membrane
Molecular Function
Protein Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Protein Binding
Zinc Ion Binding
Protein-macromolecule Adaptor Activity
Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Double-strand Break Repair Via Homologous Recombination
DNA Repair
DNA Damage Response
Protein Sumoylation
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Telomere Maintenance
Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion
Chromatin Looping
Protein Localization To Site Of Double-strand Break
Positive Regulation Of Double-strand Break Repair
Negative Regulation Of Receptor Recycling
Immune System Process
Autophagy
Golgi Organization
Signal Transduction
Intracellular Protein Localization
Cell Death
Positive Regulation Of Autophagy
Protein Localization To Golgi Apparatus
Cellular Response To Unfolded Protein
Golgi To Plasma Membrane Protein Transport
Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Defense Response To Gram-negative Bacterium
Type 2 Mitophagy
Golgi Ribbon Formation
Positive Regulation Of Xenophagy
Pathways
Regulation of PLK1 Activity at G2/M Transition
PINK1-PRKN Mediated Mitophagy
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
TBC/RABGAPs
TICAM1-dependent activation of IRF3/IRF7
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Primary open angle glaucoma
GWAS
Age at first birth (
34211149
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Lung cancer (
28604730
)
Cerebrospinal fluid p-tau levels (
29274321
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Paget's disease (
20436471
21623375
)
Interacting Genes
7 interacting genes:
CALM1
CBS
OPTN
PSMA1
SFMBT2
SMC6
TRIM14
72 interacting genes:
AIMP1
ARRDC3
ATG16L1
ATG5
CALM1
CCDC13
CDC23
CFTR
CLTC
CMYA5
DAZAP2
DYSF
DZIP1
ENTREP1
FLII
FOS
FTH1
GABARAP
GABARAPL1
GABARAPL2
GNAS
GRM1
GTF3A
HACE1
HSF2BP
HSPB1
HTT
IRAK1
KANSL1L
LITAF
LNX2
MAILR
MAP1LC3A
MAP1LC3B
MAP1LC3C
MPP1
MYH3
MYO6
PIAS4
PICK1
POU6F2
RAB11A
RAB11B
RAB12
RAB14
RAB25
RAB8A
RBM12
RFFL
RNF11
RNF216
SDCBP
SLF2
SNCA
SNX6
TBC1D15
TBC1D17
UBB
UQCRQ
USP2
VCP
WASHC3
WIPI2
WWP2
ZNF17
ZNF181
ZNF302
ZNF329
ZNF398
ZNF426
ZNF670
ZNF711
Entrez ID
55719
10133
HPRD ID
12581
03891
Ensembl ID
ENSG00000119906
ENSG00000123240
Uniprot IDs
Q8IX21
Q96CV9
PDB IDs
7T5P
2LO4
2LUE
3VTV
3VTW
5AAZ
5B83
5EOA
5EOF
7CZM
9B0B
9B0Z
9B12
9IKQ
Enriched GO Terms of Interacting Partners
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Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Adenylate Cyclase Activator Activity
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Nucleus
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Cysteine Biosynthetic Process
Cysteine Biosynthetic Process From Serine
L-serine Catabolic Process
Transsulfuration
Cysteine Biosynthetic Process Via Cystathionine
Homocysteine Catabolic Process
Hydrogen Sulfide Biosynthetic Process
Nitrite Reductase (NO-forming) Activity
Cerebellum Morphogenesis
Hydrogen Sulfide Metabolic Process
L-cysteine Catabolic Process
Cystathionine Beta-synthase Activity
Nitric Oxide Binding
Carbon Monoxide Binding
Negative Regulation Of Receptor Recycling
Type 2 Mitophagy
DNA Secondary Structure Binding
Interchromatin Granule
Chromosomal Region
Sex Chromosome
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Transporter Inhibitor Activity
Regulation Of Calcium Ion Export Across Plasma Membrane
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Positive Regulation Of Sequestering Of Calcium Ion
Autophagosome Membrane Docking
DNA Protection
Modified Amino Acid Binding
Negative Regulation Of Voltage-gated Calcium Channel Activity
Proteasome Core Complex, Alpha-subunit Complex
Positive Regulation Of Xenophagy
Smc5-Smc6 Complex
Regulation Of Nitric Oxide Mediated Signal Transduction
Response To Folic Acid
Golgi Ribbon Formation
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Sulfur Amino Acid Catabolic Process
Cysteine Metabolic Process
Serine Family Amino Acid Catabolic Process
Autophagosome
Cellular Response To Nitrogen Starvation
Cytoplasmic Vesicle
Phosphatidylethanolamine Binding
Autophagy
Autophagosome Maturation
Endosome
Autophagosome Assembly
Ubiquitin Protein Ligase Binding
Autophagosome Organization
Autophagy Of Mitochondrion
Establishment Of Protein Localization
Macroautophagy
Protein Transport
Phospholipid Binding
Autophagosome Membrane
Vacuole Organization
Mitophagy
Myosin V Binding
Cellular Response To Starvation
Establishment Of Localization In Cell
Recycling Endosome Membrane
Protein-containing Complex Disassembly
Response To Starvation
Organelle Assembly
Intracellular Transport
Recycling Endosome
Cellular Response To Nutrient Levels
Intracellular Protein Localization
Endosomal Transport
Cellular Localization
Lysosome
Beta-tubulin Binding
Centriolar Satellite
Amyloid-beta Clearance By Transcytosis
Response To Iron(II) Ion
Regulation Of Cilium Assembly
Vesicle-mediated Transport
Cellular Response To Stress
Cytoplasmic Vesicle Membrane
Cytosol
G Protein Activity
Cytoplasm
Intracellular Protein Transport
Endocytic Recycling
Regulation Of Protein Localization
Exocytosis
Endosome Membrane
Catabolic Process
Response To Nutrient Levels
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Tagcloud (Difference)
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Tagcloud (Intersection)
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