SLF2

Description		SMC5/6 complex localization factor 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm PML Body Smc5-Smc6 Complex Site Of Double-strand Break
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)
Interacting Genes		7 interacting genes: CALM1 CBS OPTN PSMA1 SFMBT2 SMC6 TRIM14
Entrez ID		55719
HPRD ID		12581
Ensembl ID		ENSG00000119906
Uniprot IDs		Q8IX21
PDB IDs		7T5P
Enriched GO Terms of Interacting Partners?		Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Nucleus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Biosynthetic Process Cysteine Biosynthetic Process From Serine L-serine Catabolic Process Transsulfuration Cysteine Biosynthetic Process Via Cystathionine Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Cystathionine Beta-synthase Activity Nitric Oxide Binding Carbon Monoxide Binding Negative Regulation Of Receptor Recycling Type 2 Mitophagy DNA Secondary Structure Binding Interchromatin Granule Chromosomal Region Sex Chromosome Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking DNA Protection Modified Amino Acid Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Proteasome Core Complex, Alpha-subunit Complex Positive Regulation Of Xenophagy Smc5-Smc6 Complex Regulation Of Nitric Oxide Mediated Signal Transduction Response To Folic Acid Golgi Ribbon Formation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process
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