SLF2 and CBS

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SLF2	CBS
Description		SMC5/6 complex localization factor 2	cystathionine beta-synthase
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm PML Body Smc5-Smc6 Complex Site Of Double-strand Break	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Catalytic Activity Cystathionine Beta-synthase Activity Protein Binding Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Protein Sumoylation Positive Regulation Of Protein-containing Complex Assembly Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair	Endochondral Ossification Blood Vessel Remodeling Cysteine Metabolic Process Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Superoxide Metabolic Process Amino Acid Biosynthetic Process Serine Family Amino Acid Metabolic Process Regulation Of Nitric Oxide Mediated Signal Transduction Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process Cerebellum Morphogenesis Response To Nutrient Levels DNA Protection Negative Regulation Of Apoptotic Process Homocysteine Catabolic Process Sulfur Compound Biosynthetic Process Regulation Of JNK Cascade Homocysteine Metabolic Process Response To Folic Acid Maternal Process Involved In Female Pregnancy Cartilage Development Involved In Endochondral Bone Morphogenesis Hydrogen Sulfide Biosynthetic Process Cellular Response To Hypoxia Blood Vessel Diameter Maintenance
Pathways			Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal phosphate Ademetionine Serine Cysteine
Diseases			Homocystinuria
GWAS		Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)	Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 20031578 23824729) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150) Serum metabolite levels ( 33031748)
Interacting Genes		7 interacting genes: CALM1 CBS OPTN PSMA1 SFMBT2 SMC6 TRIM14	35 interacting genes: ATRX CBX4 CERT1 DAXX EHHADH FAF1 FXR1 FXR2 HGS HID1 HIPK1 HTT NTAQ1 PAX6 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 SATB1 SLF2 SMARCAD1 SNCA SNRNP70 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5 ZNF181 ZNF451
Entrez ID		55719	875
HPRD ID		12581	01994
Ensembl ID		ENSG00000119906	ENSG00000160200
Uniprot IDs		Q8IX21	B7Z2D6 P35520
PDB IDs		7T5P	1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS 7QGT 8S5H 8S5I 8S5J 8S5K 8S5L 8S5M 8STW
Enriched GO Terms of Interacting Partners?		Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Nucleus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cysteine Biosynthetic Process Cysteine Biosynthetic Process From Serine L-serine Catabolic Process Transsulfuration Cysteine Biosynthetic Process Via Cystathionine Homocysteine Catabolic Process Hydrogen Sulfide Biosynthetic Process Nitrite Reductase (NO-forming) Activity Cerebellum Morphogenesis Hydrogen Sulfide Metabolic Process L-cysteine Catabolic Process Cystathionine Beta-synthase Activity Nitric Oxide Binding Carbon Monoxide Binding Negative Regulation Of Receptor Recycling Type 2 Mitophagy DNA Secondary Structure Binding Interchromatin Granule Chromosomal Region Sex Chromosome Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Autophagosome Membrane Docking DNA Protection Modified Amino Acid Binding Negative Regulation Of Voltage-gated Calcium Channel Activity Proteasome Core Complex, Alpha-subunit Complex Positive Regulation Of Xenophagy Smc5-Smc6 Complex Regulation Of Nitric Oxide Mediated Signal Transduction Response To Folic Acid Golgi Ribbon Formation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process	PML Body Protein Sumoylation SUMO Ligase Activity SUMO Transferase Activity Postsynaptic Cytosol Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Speck Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of RNA Metabolic Process Enzyme Binding Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Protein Modification Process Transcription Corepressor Activity Phosphoprotein Binding Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Macromolecule Metabolic Process CAMP-dependent Protein Kinase Regulator Activity Nuclear Body Protein Domain Specific Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Iris Morphogenesis Regulation Of Chaperone-mediated Autophagy Glutamatergic Synapse Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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