ZNF34 and TBX6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF34	TBX6
Description		zinc finger protein 34	T-box transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mesoderm Development Mesodermal Cell Fate Specification Anatomical Structure Morphogenesis Negative Regulation Of Neuron Projection Development Negative Regulation Of Neuron Maturation Signal Transduction Involved In Regulation Of Gene Expression Somite Rostral/caudal Axis Specification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Generic Transcription Pathway	Formation of paraxial mesoderm Somitogenesis Formation of the posterior neural plate
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Logical memory (immediate recall) in normal cognition ( 29274321) Type 2 diabetes ( 30054458)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244) Red blood cell count ( 29403010 27863252 32888494) Reticulocyte count ( 32888494) Schizophrenia ( 29483656 25056061) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		44 interacting genes: ANKHD1 CYSRT1 DAZAP2 DTX2 FOXH1 GCM2 HGS HOXC8 KRTAP10-5 KRTAP26-1 KRTAP8-1 LENG8 LMO2 MAPKBP1 MKRN3 NFYC OTX1 PITX1 PITX2 PLSCR4 POU6F2 RBPMS RBPMS2 ROR2 RSPH1 RUSC1 SPAG8 TBX3 TBX6 TCF7L2 TFG TIAM1 TLE5 TLX3 TRIP13 UBAP2 VAC14 VENTX VGLL3 VPS37C WDR25 YTHDF1 ZC3H10 ZIC1	39 interacting genes: ACTMAP C10orf55 C1orf94 CRX CYSRT1 DAZAP2 HSFY1 HSFY2 INTS11 KLHDC7B KRTAP11-1 KRTAP13-1 KRTAP6-2 KRTAP6-3 MAGED1 MEOX2 METTL27 MGAT5B PLA2G10 POU2AF1 POU6F2 PRMT1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 RBPMS TBX15 TBX19 TCP11L1 TENT5B TLE5 TOX4 TSC1 USP54 YPEL3 ZNF34
Entrez ID		80778	6911
HPRD ID		11772	03888
Ensembl ID		ENSG00000196378	ENSG00000149922
Uniprot IDs		A0A0C4DG42 E9PNZ6 Q8IZ26	O95947
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Myoblast Fate Commitment Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Embryonic Hindlimb Morphogenesis Pattern Specification Process Embryonic Morphogenesis Hindlimb Morphogenesis Cytoplasmic Stress Granule Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Inner Ear Morphogenesis DNA Binding Outflow Tract Morphogenesis Wnt Signaling Pathway Regionalization Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Embryonic Digestive Tract Morphogenesis Axis Specification Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Identical Protein Binding Cell Fate Specification Positive Regulation Of Metabolic Process Embryonic Limb Morphogenesis
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