DDAH2 and ATP1B1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DDAH2	ATP1B1
Gene Name		dimethylarginine dimethylaminohydrolase 2	ATPase, Na+/K+ transporting, beta 1 polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Extracellular Vesicular Exosome	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Vesicle Sarcolemma Extracellular Vesicular Exosome
	Molecular Function	Catalytic Activity Protein Binding Dimethylargininase Activity Amino Acid Binding	ATPase Activator Activity Sodium:potassium-exchanging ATPase Activity Protein Binding MHC Class II Protein Complex Binding ATPase Binding
	Biological Process	Citrulline Metabolic Process Arginine Catabolic Process Nitric Oxide Biosynthetic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process	Response To Hypoxia Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Cell Adhesion Blood Coagulation Potassium Ion Import Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Export From Cell Protein Transport Into Plasma Membrane Raft Protein Stabilization Leukocyte Migration Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export From Cell Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of Potassium Ion Import
Pathways			Ion transport by P-type ATPases Ion channel transport Basigin interactions Cell surface interactions at the vascular wall
Drugs		L-Citrulline
Diseases
GWAS			QT interval ( 23166209 19305409)
Protein-Protein Interactions		22 interactors: ANXA7 ATP1B1 CDC73 CDK4 CDKN1A DNAJB11 GADD45G MKNK1 PIN1 RAP1B RCC1 RPS6KA1 RPS6KA5 SMN1 STK3 TAF1D TK1 TNFSF11 TRIP13 TSC22D1 VAC14 ZAK	17 interactors: BACE1 BARD1 BRCA1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 KMT2B LRIF1 NDRG2 PAXIP1 PSME1 TRMT2A USP4
Entrez ID		23564	481
HPRD ID		09204	01663
Ensembl ID		ENSG00000213722	ENSG00000143153
Uniprot IDs		O95865	A3KLL5 A6NGH2 P05026
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Response To Stress Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Posttranscriptional Regulation Of Gene Expression Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Signal Transduction By Phosphorylation Response To Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Regulation Of MAPK Cascade Positive Regulation Of Cell Death Regulation Of JNK Cascade Cell Cycle Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Stress-activated MAPK Cascade Signal Transduction Regulation Of Mitotic Cell Cycle Cellular Response To Stress Positive Regulation Of MAPK Cascade Neurotrophin Signaling Pathway MAPK Cascade Developmental Process Regulation Of Cellular Process Regulation Of Cell Cycle Process Signaling	Regulation Of Histone H3-K4 Methylation Regulation Of Histone Methylation Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H3-K4 Methylation Histone Lysine Methylation Signal Transduction In Response To DNA Damage Peptidyl-lysine Methylation Nitrogen Compound Metabolic Process Nitric Oxide Biosynthetic Process Regulation Of Protein Metabolic Process Reactive Oxygen Species Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Histone Acetylation Histone Methylation Regulation Of Histone Modification Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Methylation Nitric Oxide Metabolic Process Positive Regulation Of Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Histone H3-K4 Methylation Protein Methylation Positive Regulation Of Histone Methylation Positive Regulation Of DNA Repair Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Histone Acetylation Negative Regulation Of Cell Death
Tagcloud ?		adjustment adma anova arthritis asymmetric cv ddah1 dimethylaminohydrolase dimethylarginine erythrocyte esr genotyped give homa homeostatic initially lightcycler multivariate namely polymorphisms ra relate rheumatoid sedimentation snps tag traditional variables	activin belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lhx1 lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Difference) ?		adjustment adma anova arthritis asymmetric cv ddah1 dimethylaminohydrolase dimethylarginine erythrocyte esr genotyped give homa homeostatic initially lightcycler multivariate namely polymorphisms ra relate rheumatoid sedimentation snps tag traditional variables	activin belongs bip caps elusive folding grp78 homeobox hspa5 hspa5mo knock lhx1 lim malformation morphants morpholino mos multifunctional oligonucleotides participates pax2 pronephric pronephros rescued residing serves specification unfolded xenopus
Tagcloud (Intersection) ?