LTBP3

Description		latent transforming growth factor beta binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Transforming Growth Factor Beta Binding
	Biological Process	Skeletal System Development Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs
Drugs
Diseases		Tooth agenesis; Hypodontia
GWAS		Acne (severe) ( 24927181) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Osteoarthritis (hip) ( 30374069) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 23263486) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		17 interacting genes: CACNA1A CCNG1 DYRK1A GORASP2 HBEGF HOXA1 ITGB5 MBD1 NUFIP2 PELI2 PIK3R2 PRPF40A RAC1 SHANK3 TGFB1 TGFB2 TGFB3
Entrez ID		4054
HPRD ID		03649
Ensembl ID		ENSG00000168056
Uniprot IDs		B9EG76 Q8WYU6 Q9NS15
PDB IDs
Enriched GO Terms of Interacting Partners?		Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Regulation Of Cytoskeleton Organization Transforming Growth Factor Beta Receptor Binding Regulation Of Actin Cytoskeleton Organization Uterine Wall Breakdown Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Gland Morphogenesis Positive Regulation Of Protein Transport Face Morphogenesis Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Regulation Of Macrophage Cytokine Production Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Secretion Growth Factor Activity Inner Ear Development Regulation Of Cell Division Cell-cell Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Platelet Alpha Granule Lumen Regulation Of Interleukin-23 Production Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Transport Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Protein Localization Cell Junction Organization Secondary Palate Development Regulation Of Organelle Organization Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Cell Division Positive Regulation Of Cardiocyte Differentiation Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Nucleus Odontogenesis Regulation Of Establishment Of Protein Localization Cell Migration Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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