LTBP3 and MBD1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		LTBP3	MBD1
Description		latent transforming growth factor beta binding protein 3	methyl-CpG binding domain protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding Growth Factor Binding Transforming Growth Factor Beta Binding	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding Metal Ion Binding
	Biological Process	Skeletal System Development Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs	SUMOylation of transcription cofactors
Drugs
Diseases		Tooth agenesis; Hypodontia
GWAS		Acne (severe) ( 24927181) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Osteoarthritis (hip) ( 30374069) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 23263486) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Chronic lymphocytic leukemia ( 28165464)
Interacting Genes		17 interacting genes: CACNA1A CCNG1 DYRK1A GORASP2 HBEGF HOXA1 ITGB5 MBD1 NUFIP2 PELI2 PIK3R2 PRPF40A RAC1 SHANK3 TGFB1 TGFB2 TGFB3	47 interacting genes: APP ATF7IP ATF7IP2 ATXN1L C1QBP CBX4 CBX5 CCDC136 CHAF1A COPE DVL3 ECT2 EEF1G GRN HDAC3 HIPK3 HTT HUNK JAG2 LTBP3 LTBP4 MDFI MEGF6 NELL1 NELL2 NOTCH1 NOTCH3 OASL PIAS1 PIAS2 POMGNT1 RNF2 SETDB1 SLC25A3 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SNAPC2 SP1 SUV39H1 TENM1 TIAM1 TNC ZNF384 ZNF512B
Entrez ID		4054	4152
HPRD ID		03649	01133
Ensembl ID		ENSG00000168056	ENSG00000141644
Uniprot IDs		B9EG76 Q8WYU6 Q9NS15	A0A994J7H0 A8K654 B4DI41 B4DUR3 Q9UIS9
PDB IDs			1D9N 1IG4 4D4W 5W9Q 6D1T
Enriched GO Terms of Interacting Partners?		Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Regulation Of Cytoskeleton Organization Transforming Growth Factor Beta Receptor Binding Regulation Of Actin Cytoskeleton Organization Uterine Wall Breakdown Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Gland Morphogenesis Positive Regulation Of Protein Transport Face Morphogenesis Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Regulation Of Macrophage Cytokine Production Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Secretion Growth Factor Activity Inner Ear Development Regulation Of Cell Division Cell-cell Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Platelet Alpha Granule Lumen Regulation Of Interleukin-23 Production Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Transport Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Protein Localization Cell Junction Organization Secondary Palate Development Regulation Of Organelle Organization Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Cell Division Positive Regulation Of Cardiocyte Differentiation Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Nucleus Odontogenesis Regulation Of Establishment Of Protein Localization Cell Migration Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Heteromeric SMAD Protein Complex SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ossification DEAD/H-box RNA Helicase Binding Positive Regulation Of Developmental Process Transcription Corepressor Activity Kidney Epithelium Development Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Nucleus Regulation Of Cell Population Proliferation Regulation Of MiRNA Metabolic Process Ureteric Bud Development SUMO Ligase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ossification Nucleoplasm Mesonephric Tubule Development Mesonephric Epithelium Development Epigenetic Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Auditory Receptor Cell Fate Commitment Osteoblast Fate Commitment SUMO Transferase Activity
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