PRKAG2

Gene Name		protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytosol AMP-activated Protein Kinase Complex
	Molecular Function	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycolytic Process Energy Reserve Metabolic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Membrane Organization Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Bipolar disorder (age of onset and psychomotor symptoms) ( 21305692) Chronic kidney disease ( 20383146) Hematocrit ( 19862010) Hemoglobin ( 19862010) Red blood cell traits ( 23222517) Urate levels ( 23263486)
Protein-protein Interactions		3 interactors: PRKAB1 PRKAB2 PRKAG1
Entrez ID		51422
HPRD ID		04119
Ensembl ID		ENSG00000106617
Uniprot IDs		G8JLM0 Q9UGJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Fatty Acid Biosynthetic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Fatty Acid Metabolic Process Cellular Response To Peptide Mitochondrion Organization Negative Regulation Of Cell Cycle Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Membrane Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cell Cycle Process Protein Heterooligomerization Regulation Of Protein Phosphorylation Organic Acid Metabolic Process Lipid Metabolic Process Regulation Of Phosphorylation Protein Phosphorylation Cell Cycle Regulation Of Phosphorus Metabolic Process Phosphorylation Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein Oligomerization Small Molecule Metabolic Process Carnitine Shuttle Regulation Of Catalytic Activity Response To Organic Substance Carnitine Transmembrane Transport Carnitine Transport Phosphate-containing Compound Metabolic Process Quaternary Ammonium Group Transport Cell Surface Receptor Signaling Pathway Organelle Organization
Tagcloud ?		aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian replicated rheumatology sizes slc16a9 slc22a11 urate zealand