PRKAG2

Description		protein kinase AMP-activated non-catalytic subunit gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Nucleotide Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycolytic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process ATP Biosynthetic Process Sterol Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Cellular Response To Nutrient Levels Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Positive Regulation Of Gluconeogenesis Regulation Of Fatty Acid Oxidation Regulation Of D-glucose Import Regulation Of Cell Cycle
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Bipolar disorder (age of onset and psychotic symptoms) ( 21305692) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 20383146 26831199 31152163) Creatinine levels ( 31015462) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate (creatinine, CKDi25) ( 33137338) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Gout ( 33832965) Gut microbiota (beta diversity) ( 27723756) Hematocrit ( 19862010 32888494 28017375 27863252) Hemoglobin ( 19862010 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) Intraocular pressure ( 29785010 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878 30578418) Red blood cell count ( 28453575 27863252 32888494) Red blood cell traits ( 23222517) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 30578418 27618447) Urate levels ( 23263486 31578528) Urea levels ( 28270201 31015462) Urinary albumin excretion ( 32277301)
Novel Interacting Genes		1 novel interacting genes: CHPF2
Interacting Genes		6 interacting genes: DAPK1 MFHAS1 PRKAB1 PRKAB2 PRKAG1 SLC31A1
Entrez ID		51422
HPRD ID		04119
Ensembl ID		ENSG00000106617
Uniprot IDs		A0A090N8Q6 A0A384MDZ2 A0A494C068 A0A494C155 A0A494C1K7 B7Z6X8 E9PGP6 Q9UGJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-activated Protein Kinase Complex AMP-activated Protein Kinase Activity Fatty Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Cellular Response To Nutrient Levels Fatty Acid Metabolic Process Silver Ion Transmembrane Transporter Activity Silver Ion Transmembrane Transport Plasma Membrane Copper Ion Transport DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Small Molecule Biosynthetic Process Protein Kinase Binding Monocarboxylic Acid Metabolic Process Response To Nutrient Levels Positive Regulation Of Cold-induced Thermogenesis Lipid Biosynthetic Process Regulation Of Carbon Utilization N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity Signal Transduction Regulation Of NMDA Receptor Activity Regulation Of Cold-induced Thermogenesis Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Copper Ion Import Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Nail Development CAMP-dependent Protein Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity Copper Ion Transmembrane Transporter Activity CAMP-dependent Protein Kinase Regulator Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Acetylgalactosaminyltransferase Activity Copper Ion Transmembrane Transport Cellular Response To Hydroperoxide Defense Response To Tumor Cell AMP Binding Copper Ion Transport Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Intracellular Copper Ion Homeostasis Regulation Of Neurotransmitter Receptor Activity Protein Kinase Regulator Activity Lipid Metabolic Process Copper Ion Homeostasis Syntaxin-1 Binding Chondroitin Sulfate Proteoglycan Biosynthetic Process Protein Phosphorylation Response To Hydroperoxide
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