PRKAA1 and MAP3K7

Number of citations of the paper that reports this interaction (PMID 20538596)
11

Data Source:
BioGRID (enzymatic study)

		PRKAA1	MAP3K7
Gene Name		protein kinase, AMP-activated, alpha 1 catalytic subunit	mitogen-activated protein kinase kinase kinase 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Apical Plasma Membrane AMP-activated Protein Kinase Complex	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Cytosol Plasma Membrane IkappaB Kinase Complex Endosome Membrane
	Molecular Function	Chromatin Binding Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Kinase Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Tau-protein Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Scaffold Protein Binding
	Biological Process	Activation Of MAPK Activity Response To Hypoxia Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Cell Cycle Arrest Signal Transduction Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Response To UV Cold Acclimation Response To Gamma Radiation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Response To Activity Wnt Signaling Pathway Fatty Acid Oxidation Response To Caffeine Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Rhythmic Process Negative Regulation Of Lipid Catabolic Process Protein Heterooligomerization Fatty Acid Homeostasis Regulation Of Vesicle-mediated Transport Cellular Response To Hydrogen Peroxide Cellular Response To Ethanol Cellular Response To Hypoxia Response To Camptothecin Regulation Of Energy Homeostasis Negative Regulation Of Glucose Import In Response To Insulin Stimulus	Activation Of MAPKK Activity Activation Of MAPK Activity Angiogenesis Neural Tube Formation Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Interleukin-2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation Innate Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Signaling by the B Cell Receptor (BCR) Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Signaling by Wnt Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade beta-catenin independent WNT signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Ca2+ pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs		Adenosine monophosphate Adenosine triphosphate Phenformin
Diseases
GWAS		Gastric cancer ( 22037551)	Celiac disease ( 20190752) Graves' disease ( 21841780)
Protein-Protein Interactions		58 interactors: ABI2 ACACA AES BHLHE40 CAB39 CDX4 CFTR CRTC2 CTBP1 EEF2K EPM2A FNIP1 GATA1 GOLGA2 GRIK2 HDAC5 HMBOX1 HOMEZ IKZF3 INO80E KRT40 L3MBTL3 MAP3K7 MDM4 MORC4 MTOR MTUS2 PFKFB2 PHC2 PLEKHA4 PNMA5 PPP2CA PRKAB1 PRKAB2 PRKAG1 PRKAG3 PSMD11 RAD54B RAF1 RBPMS RFX6 RIMBP3 ROPN1 RPTOR SRPK2 SSX2IP STK11 THAP1 TOMM34 TRIM27 TRIP6 TSC2 TSC22D4 TXNIP UBXN11 VPS37B VPS52 ZBED1	60 interactors: BBS10 BCL10 CARD11 CHUK COPS5 EIF2AK2 EZH2 FOS GPR25 HGS HIPK2 IKBKAP IKBKB IL17RD IRAK1 MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS NAIP NDUFS6 NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAA1 PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB TAB1 TAB2 TGFBR1 TNFRSF11A TRAF3IP2 TRAF6 TRIM8 VRK2 XIAP ZNF593 ZNF746
Entrez ID		5562	6885
HPRD ID		04115	04011
Ensembl ID		ENSG00000132356	ENSG00000135341
Uniprot IDs		Q13131	O43318
PDB IDs			2EVA 2YIY 4GS6 4L3P 4L52 4L53
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Response To Hormone Cell Cycle Arrest Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Gene Expression Response To Organonitrogen Compound Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Biosynthetic Process Cell Cycle Response To Organic Substance Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Protein Oligomerization RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Protein Heterooligomerization Negative Regulation Of Transcription, DNA-templated Protein Phosphorylation	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction By Phosphorylation Signal Transduction Regulation Of Phosphorylation MAPK Cascade Regulation Of Protein Metabolic Process Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of MAPK Cascade Phosphorylation Intracellular Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 9 Signaling Pathway Stress-activated MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stimulus MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Stimulus Regulation Of MAP Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response
Tagcloud ?		abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant	abrogated accounts bcr called card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies kappab late maguk mathematical modeling module nf residue scaffolding serine steep switch switchlike tak1 threshold
Tagcloud (Difference) ?		abeta anticipate atg7 autophagic autophagy catabolic clearance cultures degraded degrades enhancing extracellular fibrils inflammasome ingests interacts knockout lysosomal map1lc3b microglia microglial native nlr nlrp3 optineurin optn promising pyrin resultant	abrogated accounts bcr called card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies kappab late maguk mathematical modeling module nf residue scaffolding serine steep switch switchlike tak1 threshold
Tagcloud (Intersection) ?