CDC7 and ZBTB8B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDC7	ZBTB8B
Description		cell division cycle 7	zinc finger and BTB domain containing 8B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Division	Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 21307088 31798171 28073927 25631615) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Plateletcrit ( 32888494) PR interval ( 32439900) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 28073927 25241763 31798171) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B	9 interacting genes: CDC7 LMO1 LMO3 MATCAP1 MORF4L1 NTAQ1 SGTA SPATC1L UBQLN1
Entrez ID		8317	728116
HPRD ID		10345
Ensembl ID		ENSG00000097046	ENSG00000273274
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	Q8NAP8
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region DNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Replication Origin Binding Single-stranded DNA Helicase Activity Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Single-stranded DNA Binding Mitotic DNA Replication Initiation Regulation Of Metabolic Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Repair Double-strand Break Repair Via Homologous Recombination DNA Damage Response Recombinational Repair DNA Helicase Activity Positive Regulation Of DNA Replication Dbf4-dependent Protein Kinase Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Mitotic Cell Cycle DNA Strand Elongation Mesoderm Development Chromatin Organization Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Protein-N-terminal Glutamine Amidohydrolase Activity TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Tubulin-tyrosine Carboxypeptidase Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress BAT3 Complex Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair
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