CDC7 and HOMEZ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDC7	HOMEZ
Description		cell division cycle 7	homeobox and leucine zipper encoding
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Division	Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 21307088 31798171 28073927 25631615) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Plateletcrit ( 32888494) PR interval ( 32439900) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 28073927 25241763 31798171) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 27841878)
Interacting Genes		52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B	114 interacting genes: ACTR10 AEN ANKRD11 ANKRD2 ARHGAP9 ASB6 AXIN1 BIVM BYSL C2orf42 CBX8 CCDC13 CCDC187 CCHCR1 CCNK CDC7 CENPS CENPS-CORT CFAP206 CTNNA3 DEF6 DGCR6 DHX16 DNTTIP1 DRC4 EBF1 EIF4E2 ELOA ENKD1 FAM90A1 FARS2 GFAP GPANK1 GRB2 HOXC8 HSF2BP IL16 INO80B JAKMIP2 KIFC3 KPNA2 LENG1 LGALS4 LMO1 LMO3 LNX1 LRRC7 LSM4 MAD2L1BP MAFG MAPK1 MED18 MORF4L2 MOS MRPL11 NCK1 NCK2 NEIL2 NEK6 NXF1 OSGIN1 PARVG PHF1 PHF19 PIBF1 PIN1 PLEKHA7 POLDIP3 PRKAA1 PRKAA2 PRPF18 PSMA1 RASL10A RBM39 RNF8 RPGR RPL9 RPP25 RPS25 SCNM1 SDCBP SEC23A SH3RF2 SMARCB1 SMARCD1 SMYD1 SNRPB2 SUMO2 SUMO3 TARS2 TBC1D30 TCEA2 TCEANC TEAD4 TLE5 TRAF4 TSGA10IP TXK USF1 VEZF1 VPS9D1 ZBTB25 ZBTB7A ZMYND19 ZNF165 ZNF250 ZNF280C ZNF35 ZNF417 ZNF580 ZNF629 ZNF688 ZNF76 ZSCAN5B
Entrez ID		8317	57594
HPRD ID		10345	12167
Ensembl ID		ENSG00000097046	ENSG00000290292
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	Q8IX15
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8	2ECC 2YS9
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region DNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Replication Origin Binding Single-stranded DNA Helicase Activity Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Single-stranded DNA Binding Mitotic DNA Replication Initiation Regulation Of Metabolic Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Repair Double-strand Break Repair Via Homologous Recombination DNA Damage Response Recombinational Repair DNA Helicase Activity Positive Regulation Of DNA Replication Dbf4-dependent Protein Kinase Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Mitotic Cell Cycle DNA Strand Elongation Mesoderm Development Chromatin Organization Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity	Nucleus Nucleoplasm Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Ciliary Basal Body Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Metabolic Process Nucleic Acid Metabolic Process Zinc Ion Binding Nuclear Speck Zonula Adherens Maintenance Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Protein Localization To Lipid Droplet Microtubule Cytoskeleton Positive Regulation Of DNA Repair Centrosome Cytoskeletal Anchor Activity Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress DNA Binding Cellular Response To Stress Adherens Junction Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Positive Regulation Of DNA Metabolic Process Protein K6-linked Ubiquitination Regulation Of DNA-templated Transcription Elongation DNA Damage Response Regulation Of Translational Initiation Regulation Of Sister Chromatid Segregation Microtubule Cytoskeleton Organization Positive Regulation Of Translation In Response To Stress Histone H3K36me3 Reader Activity Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process
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