CDC7 and NDUFB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDC7	NDUFB2
Description		cell division cycle 7	NADH:ubiquinone oxidoreductase subunit B2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Division	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 21307088 31798171 28073927 25631615) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Plateletcrit ( 32888494) PR interval ( 32439900) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 28073927 25241763 31798171) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B	6 interacting genes: AGR2 CDC7 LCN2 MEOX2 NDUFB7 PFKM
Entrez ID		8317	4708
HPRD ID		10345	11953
Ensembl ID		ENSG00000097046	ENSG00000090266
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	A4D1T5 O95178
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region DNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Replication Origin Binding Single-stranded DNA Helicase Activity Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Single-stranded DNA Binding Mitotic DNA Replication Initiation Regulation Of Metabolic Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Repair Double-strand Break Repair Via Homologous Recombination DNA Damage Response Recombinational Repair DNA Helicase Activity Positive Regulation Of DNA Replication Dbf4-dependent Protein Kinase Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Mitotic Cell Cycle DNA Strand Elongation Mesoderm Development Chromatin Organization Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity	Positive Regulation Of Macromolecule Metabolic Process Response To Herbicide Positive Regulation Of Metabolic Process Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Hippocampal Neuron Apoptotic Process Siderophore Transport Cytoplasmic Vesicle Lumen Response To Mycotoxin Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Somite Specification ATP Metabolic Process Energy Derivation By Oxidation Of Organic Compounds 6-phosphofructokinase Activity Fructose-6-phosphate Binding Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate 6-phosphofructokinase Complex Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Endothelial Cell Migration Regulation Of Iron Ion Transport Response To Blue Light Response To Iron(II) Ion Regulation Of Endothelial Tube Morphogenesis Fructose Binding Positive Regulation Of Nuclear Cell Cycle DNA Replication Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To X-ray Response To Fructose Dystroglycan Binding Purine Ribonucleotide Metabolic Process Short-term Memory Cellular Response To Increased Oxygen Levels Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Double-strand Break Repair Via Break-induced Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Generation Of Precursor Metabolites And Energy Fructose 6-phosphate Metabolic Process Cellular Response To Interleukin-6 Segment Specification Somite Development Positive Regulation Of DNA-templated DNA Replication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?