PI4K2A and ECSIT

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		PI4K2A	ECSIT
Gene Name		phosphatidylinositol 4-kinase type 2 alpha	ECSIT signalling integrator
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Endosome Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Membrane Cell Junction Dendrite Synaptic Vesicle Membrane BLOC-1 Complex Intrinsic Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Growing Cell Tip Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Host Cell Presynaptic Membrane Membrane Raft Exocytic Vesicle	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Mitochondrion
	Molecular Function	Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding AP-3 Adaptor Complex Binding	Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H
	Biological Process	Basophil Degranulation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation	Mesoderm Formation BMP Signaling Pathway Innate Immune Response Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP CD63 ECSIT NOS3 RAD23A	42 interactors: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CYP2C18 CYP2C8 CYP2C9 DNAJB1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MAST1 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		55361	51295
HPRD ID		11431	12225
Ensembl ID		ENSG00000155252	ENSG00000130159
Uniprot IDs		Q9BTU6	K7EMM0 Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Response To Stress Platelet Degranulation Regulation Of Oxidoreductase Activity Regulation Of Body Fluid Levels Wound Healing Response To Wounding Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Platelet Activation Smooth Muscle Adaptation Collateral Sprouting Regulation Of Systemic Arterial Blood Pressure By Endothelin Axon Midline Choice Point Recognition Negative Regulation Of Muscle Hyperplasia Regulation Of Rubidium Ion Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Translation Axon Choice Point Recognition Locomotion Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Catabolic Process Pigment Granule Maturation Endosome To Melanosome Transport Cellular Response To Stimulus Neuron Remodeling Exocytosis Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Movement Of Cell Or Subcellular Component Ovulation From Ovarian Follicle Negative Regulation Of Hydrolase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Metabolic Process Nitric Oxide Mediated Signal Transduction Posttranscriptional Regulation Of Gene Expression Positive Regulation Of CGMP Biosynthetic Process Negative Regulation Of Platelet Activation Cellular Copper Ion Homeostasis Response To External Stimulus Positive Regulation Of Receptor Internalization Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Positive Regulation Of MRNA Catabolic Process Ovulation	Membrane Protein Proteolysis Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Interleukin-1 Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Epoxygenase P450 Pathway Membrane Protein Intracellular Domain Proteolysis Catabolic Process Response To Oxidative Stress Exogenous Drug Catabolic Process Drug Catabolic Process Response To Abiotic Stimulus Response To Interleukin-1 Protein Metabolic Process Response To Stress Exocytosis Negative Regulation Of Cell Death Proteolysis Response To Stimulus T Cell Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Drug Metabolic Process Cellular Response To Growth Factor Stimulus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway NIK/NF-kappaB Signaling Response To Growth Factor Regulation Of Innate Immune Response Antigen Receptor-mediated Signaling Pathway Cellular Response To Nicotine Positive Regulation Of Interleukin-12 Biosynthetic Process Omega-hydroxylase P450 Pathway Cellular Response To Stimulus Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Apoptotic Process Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Programmed Cell Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Interleukin-12 Production TRIF-dependent Toll-like Receptor Signaling Pathway Secretion By Cell Response To Drug SMAD Protein Complex Assembly Arachidonic Acid Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		attachment claims cognate endosomes ethylmaleimide fairly iialpha owing perinuclear phosphatidylinositol phospholipids promiscuous ptdins4p q recycling reside retrograde segregation shielding snare snares subcellular trafficking transferrin tubulo vamp3 vesicle vesicular vti1a	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Difference) ?		attachment claims cognate endosomes ethylmaleimide fairly iialpha owing perinuclear phosphatidylinositol phospholipids promiscuous ptdins4p q recycling reside retrograde segregation shielding snare snares subcellular trafficking transferrin tubulo vamp3 vesicle vesicular vti1a	1beta abolished adapter attributed augments consequence cytotrap evidenced evolutionarily gst hbx hbxdelta51 helenalin hepatitis ikappabalpha ikk interacted interacting kappab knockdown mechanistically nf p50 p65 pull tlr toll transactivates transfection
Tagcloud (Intersection) ?