PI4K2A and NOS3

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		PI4K2A	NOS3
Gene Name		phosphatidylinositol 4-kinase type 2 alpha	nitric oxide synthase 3 (endothelial cell)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Endosome Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Membrane Cell Junction Dendrite Synaptic Vesicle Membrane BLOC-1 Complex Intrinsic Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Growing Cell Tip Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Host Cell Presynaptic Membrane Membrane Raft Exocytic Vesicle	Golgi Membrane Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Caveola Endocytic Vesicle Membrane
	Molecular Function	Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding AP-3 Adaptor Complex Binding	Actin Monomer Binding NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Cadmium Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Basophil Degranulation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation	Angiogenesis Ovulation From Ovarian Follicle In Utero Embryonic Development Blood Vessel Remodeling Regulation Of Sodium Ion Transport Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Systemic Arterial Blood Pressure By Endothelin Arginine Catabolic Process Nitric Oxide Biosynthetic Process Mitochondrion Organization Nitric Oxide Mediated Signal Transduction Blood Coagulation Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Heat Negative Regulation Of Platelet Activation Negative Regulation Of Muscle Hyperplasia Smooth Muscle Hyperplasia Lung Development Positive Regulation Of Guanylate Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Fluid Shear Stress Negative Regulation Of Potassium Ion Transport Endothelial Cell Migration Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Nitric Oxide Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Blood Vessel Size Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Hydrolase Activity Interaction With Host Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Phagosome Maturation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism	Phagosomal maturation (early endosomal stage) VEGFA-VEGFR2 Pathway eNOS activation Metabolism of nitric oxide Platelet homeostasis Signaling by VEGF VEGFR2 mediated vascular permeability NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Latent infection of Homo sapiens with Mycobacterium tuberculosis Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase eNOS activation and regulation
Drugs			L-Arginine L-Citrulline Tetrahydrobiopterin Miconazole N,N-dimethylarginine L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide L-2-Amino-4-(Guanidinooxy)Butyric Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N\'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine 1,2,4-Triazole-Carboxamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide S,S\'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 7-Nitroindazole Ethylisothiourea 2-Aminothiazoline Se-Ethyl-Isoselenourea (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane Hydroxydimethylarsine Oxide Heme 7-Nitroindazole-2-Carboxamidine 6-Nitroindazole N-Omega-Hydroxy-L-Arginine N5-Iminoethyl-L-Ornithine 5,6-Cyclic-Tetrahydropteridine S-Ethyl-N-Phenyl-Isothiourea S,S\'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea 6s-5,6,7,8-Tetrahydrobiopterin S-(Dimethylarsenic)Cysteine L-Homoarginine S-Isopropyl-Isothiourea Nitroarginine 5-Nitroindazole N-(Chlorophenyl)-N\'-Hydroxyguanidine (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N\'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N\'-(3-chlorobenzyl)ethane-1,2-diamine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP CD63 ECSIT NOS3 RAD23A	46 interactors: A2M ACTN2 ACTN4 AGTR1 AKT1 APOE APP BDKRB2 BDNF CALM1 CAV1 CDC37 CEP55 EDNRB EFEMP1 EFEMP2 ELAVL1 ELAVL3 EXOC6 EXOSC1 FIS1 GCDH GOLGA2 H3F3A HSP90AA1 HTRA1 IMMT KANK2 MAGEA11 MAST1 MPRIP NMT1 NOSIP NOSTRIN PAXIP1 PI4K2A PPP2R5A PSEN1 PSEN2 RNF31 RNF32 SP1 ST13 TECR TXNDC11 UMPS
Entrez ID		55361	4846
HPRD ID		11431	01224
Ensembl ID		ENSG00000155252	ENSG00000164867
Uniprot IDs		Q9BTU6	A0S0A6 P29474
PDB IDs			1M9J 1M9K 1M9M 1M9Q 1M9R 1NIW 2LL7 3EAH 3NOS
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Response To Stress Platelet Degranulation Regulation Of Oxidoreductase Activity Regulation Of Body Fluid Levels Wound Healing Response To Wounding Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Platelet Activation Smooth Muscle Adaptation Collateral Sprouting Regulation Of Systemic Arterial Blood Pressure By Endothelin Axon Midline Choice Point Recognition Negative Regulation Of Muscle Hyperplasia Regulation Of Rubidium Ion Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Translation Axon Choice Point Recognition Locomotion Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Catabolic Process Pigment Granule Maturation Endosome To Melanosome Transport Cellular Response To Stimulus Neuron Remodeling Exocytosis Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Movement Of Cell Or Subcellular Component Ovulation From Ovarian Follicle Negative Regulation Of Hydrolase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Metabolic Process Nitric Oxide Mediated Signal Transduction Posttranscriptional Regulation Of Gene Expression Positive Regulation Of CGMP Biosynthetic Process Negative Regulation Of Platelet Activation Cellular Copper Ion Homeostasis Response To External Stimulus Positive Regulation Of Receptor Internalization Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Positive Regulation Of MRNA Catabolic Process Ovulation	Regulation Of Nitric-oxide Synthase Activity Regulation Of Oxidoreductase Activity Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Secretion Cellular Metal Ion Homeostasis Regulation Of Cellular Protein Metabolic Process Cellular Cation Homeostasis Regulation Of Body Fluid Levels Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Regulation Of Cellular Amino Acid Metabolic Process Cellular Homeostasis Response To Abiotic Stimulus Ion Homeostasis Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation Homeostatic Process Hemostasis Reactive Oxygen Species Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Exocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Platelet Degranulation Regulation Of Blood Vessel Size Secretion By Cell Chemical Homeostasis Regulation Of Tube Size Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Metabolic Process Response To Wounding Negative Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ion Transport Wound Healing Establishment Of Localization In Cell Signaling Signal Transduction Negative Regulation Of Protein Phosphorylation Platelet Activation Positive Regulation Of Ion Transport Regulation Of Catalytic Activity Cell Communication Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		attachment claims cognate endosomes ethylmaleimide fairly iialpha owing perinuclear phosphatidylinositol phospholipids promiscuous ptdins4p q recycling reside retrograde segregation shielding snare snares subcellular trafficking transferrin tubulo vamp3 vesicle vesicular vti1a	antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal
Tagcloud (Difference) ?		attachment claims cognate endosomes ethylmaleimide fairly iialpha owing perinuclear phosphatidylinositol phospholipids promiscuous ptdins4p q recycling reside retrograde segregation shielding snare snares subcellular trafficking transferrin tubulo vamp3 vesicle vesicular vti1a	antidepressants attacks bed favorable genotype genotypes gg glu298asp gt headaches instructed invited medications migraine month night nortriptyline numerical participate polymorphism prophylaxis rating rd st tcas tricyclic tt verbal
Tagcloud (Intersection) ?