PI4K2A and RAD23A

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		PI4K2A	RAD23A
Description		phosphatidylinositol 4-kinase type 2 alpha	RAD23 nucleotide excision repair protein A
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GO Annotations	Cellular Component	Golgi Membrane Mitochondrion Lysosomal Membrane Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endosome Membrane Membrane Dendrite BLOC-1 Complex Cytoplasmic Vesicle Early Endosome Membrane Growing Cell Tip Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft Synapse Presynaptic Active Zone Glutamatergic Synapse	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity AP-3 Adaptor Complex Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Proteasome Binding Ubiquitin-specific Protease Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphate Biosynthetic Process	DNA Repair Nucleotide-excision Repair DNA Damage Response Protein Destabilization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Cell Cycle
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane	Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS			Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		7 interacting genes: APP CD63 ECSIT HRAS NOS3 OGT RAD23A	79 interacting genes: A2M ADRM1 ANKRD40 ATXN3 ATXN7 CCNA2 CDC37 CEBPA CHEK1 CNTROB CREBBP DAZAP2 DBI ECSIT EP300 EWSR1 FILIP1 GTF2H1 H4C1 HSPB1 IFIT3 IFIT5 KRTAP12-2 LOXL4 MAP3K1 MAST1 MDM2 MINDY3 MKRN1 MPG NEDD8 NGLY1 NUTM2F OGT PDE6D PHAX PI4K2A PRKN PSEN1 PSMC5 PSMD4 RABGEF1 REL RNF115 RNF32 RNF41 RPN1 RPS27A SH3RF1 SMURF1 SQSTM1 TNFAIP3 TRAF2 TRAF3 TRAF5 TRAF6 TRIM39 TRIM50 TRIM54 TRIM55 TRIM8 TRIP6 UBA52 UBB UBC UBE3A UBE4B UBL7 UBQLN4 UBXN1 UIMC1 USP25 VAV2 WWP2 XPC ZBTB26 ZBTB44 ZBTB8A ZFAND6
Entrez ID		55361	5886
HPRD ID		11431	07191
Ensembl ID		ENSG00000155252	ENSG00000179262
Uniprot IDs		Q9BTU6	A8K1J3 P54725
PDB IDs		4HND 4HNE 4PLA 4YC4 5EUT 5I0N	1DV0 1F4I 1IFY 1OQY 1P98 1P9D 1QZE 1TP4 2WYQ 5XBO 6W2G 6W2H 6W2I 6XQI 6XQJ 7TGP 8Q06
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Migration Regulation Of Locomotion Regulation Of Cell Motility Endosome Lumen Positive Regulation Of Receptor Internalization Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Synapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Biological Quality Protein-containing Complex Positive Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Glycolytic Process Intracellular Signaling Cassette Response To Stress Positive Regulation Of Signaling Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Neuronal Synaptic Plasticity Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Type II Interferon Production Regulation Of Protein Catabolic Process Regulation Of Metal Ion Transport Regulation Of Receptor Internalization Glial Cell Development Pigment Granule Maturation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Monoatomic Ion Transport Regulation Of Purine Nucleotide Metabolic Process Regulation Of Potassium Ion Transport Regulation Of MiRNA Metabolic Process Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression Positive Regulation Of JNK Cascade Lipoprotein Particle Positive Regulation Of Protein Import GTPase Complex Smooth Muscle Hyperplasia Negative Regulation Of Muscle Hyperplasia	Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Protein Polyubiquitination Protein Autoubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Proteasomal Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Zinc Ion Binding Regulation Of Protein Metabolic Process Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activity Cytoplasm Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Protein K48-linked Deubiquitination CD40 Receptor Complex Transferase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Catabolic Process Canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Ubiquitin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Immune Response-regulating Cell Surface Receptor Signaling Pathway Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signaling
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