PPP5C and GNA13

Number of citations of the paper that reports this interaction (PubMedID 12176367)
0

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PPP5C	GNA13
Description		protein phosphatase 5 catalytic subunit	G protein subunit alpha 13
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex Neuronal Cell Body Perikaryon Protein Folding Chaperone Complex Proximal Dendrite	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome Postsynapse
	Molecular Function	G-protein Alpha-subunit Binding RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Hydrolase Activity Phosphatase Activity Protein Serine/threonine Kinase Inhibitor Activity Hsp70 Protein Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding ADP Binding Protein-containing Complex Binding Metal Ion Binding Tau Protein Binding Hsp90 Protein Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	MAPK Cascade Mitotic Cell Cycle DNA Repair Double-strand Break Repair DNA-templated Transcription DNA Damage Response Response To Lead Ion Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Negative Regulation Of MAPK Cascade Peptidyl-serine Dephosphorylation Cellular Response To Hydrogen Peroxide Cellular Response To Cadmium Ion Response To Arachidonate Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Regulation Of Cell Shape Regulation Of Fibroblast Migration Cell Differentiation Platelet Activation Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling	NRAGE signals death through JNK G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		ATP
Diseases
GWAS		Basophil percentage of white cells ( 27863252) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Neuroticism ( 29255261) Response to antidepressants in depression ( 29998114) Triglyceride levels ( 32203549)	Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)
Interacting Genes		30 interacting genes: APP BRWD1 CDC16 CDC27 CDC37 CDK20 CEBPA CHORDC1 CPNE1 CPNE2 CPNE4 CRY2 CSE1L CSNK1D DISC1 EGFR ESR2 GNA12 GNA13 HSP90AA1 HTR2A HUWE1 MAP3K5 MAP3K7 MAPT OGT PPP2R1A PPP2R3A SIM2 VHL	31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR
Entrez ID		5536	10672
HPRD ID		02805	05100
Ensembl ID		ENSG00000011485	ENSG00000120063
Uniprot IDs		P53041	Q14344
PDB IDs		1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69 4ZVZ 4ZX2 5HPE 5UI1 5WG8 7ZR5 7ZR6 8GAE 8GFT	7SF7 7SF8 7T6B 7YDH 8H8J 8KGG 8ZX4 8ZX5 9GE2 9GE3 9IY8 9IZH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication D5 Dopamine Receptor Binding Neurofibrillary Tangle Assembly Protein Branched Polyubiquitination Circadian Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Binding MAP Kinase Kinase Kinase Activity Protein Localization To Organelle Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Metabolic Process Response To Metal Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphatase Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Main Axon Kinase Binding Regulation Of Gene Expression Regulation Of Proteolysis Rho-activating G Protein-coupled Receptor Signaling Pathway Hsp90 Protein Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Memory Regulation Of Cell Cycle Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Circadian Rhythm Protein Localization To Cytoskeleton Positive Regulation Of Cell Differentiation	G Protein-coupled Receptor Signaling Pathway Signal Transduction Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Oxygen-containing Compound Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette G Protein-coupled Receptor Binding Sphingosine-1-phosphate Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Vasculature Development Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Modulation Of Chemical Synaptic Transmission Guanyl-nucleotide Exchange Factor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Sphingolipid Mediated Signaling Pathway Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Lipid Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Blood Pressure Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Catenin Complex Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity G-protein Alpha-subunit Binding Cell Migration Lamellipodium Regulation Of Protein Localization Regulation Of Vasculature Development Regulation Of Developmental Process Cellular Response To Indole-3-methanol
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