PPP5C and CHORDC1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		PPP5C	CHORDC1
Description		protein phosphatase 5 catalytic subunit	cysteine and histidine rich domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex Neuronal Cell Body Perikaryon Protein Folding Chaperone Complex Proximal Dendrite
	Molecular Function	G-protein Alpha-subunit Binding RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Hydrolase Activity Phosphatase Activity Protein Serine/threonine Kinase Inhibitor Activity Hsp70 Protein Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding ADP Binding Protein-containing Complex Binding Metal Ion Binding Tau Protein Binding Hsp90 Protein Binding	Protein Binding ATP Binding Zinc Ion Binding ADP Binding Metal Ion Binding Hsp90 Protein Binding
	Biological Process	MAPK Cascade Mitotic Cell Cycle DNA Repair Double-strand Break Repair DNA-templated Transcription DNA Damage Response Response To Lead Ion Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Negative Regulation Of MAPK Cascade Peptidyl-serine Dephosphorylation Cellular Response To Hydrogen Peroxide Cellular Response To Cadmium Ion Response To Arachidonate Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Protein Folding Regulation Of Centrosome Duplication Centrosome Duplication Regulation Of Cellular Response To Heat
Pathways		Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling
Drugs		ATP
Diseases
GWAS		Basophil percentage of white cells ( 27863252) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Neuroticism ( 29255261) Response to antidepressants in depression ( 29998114) Triglyceride levels ( 32203549)	Basophil count ( 32888494) Basophil percentage of white cells ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		30 interacting genes: APP BRWD1 CDC16 CDC27 CDC37 CDK20 CEBPA CHORDC1 CPNE1 CPNE2 CPNE4 CRY2 CSE1L CSNK1D DISC1 EGFR ESR2 GNA12 GNA13 HSP90AA1 HTR2A HUWE1 MAP3K5 MAP3K7 MAPT OGT PPP2R1A PPP2R3A SIM2 VHL	7 interacting genes: HSP90AA1 HSP90AB1 NAP1L1 PAK1 PPP5C TCAP XPO1
Entrez ID		5536	26973
HPRD ID		02805	05072
Ensembl ID		ENSG00000011485	ENSG00000110172
Uniprot IDs		P53041	E9PPQ5 Q9UHD1
PDB IDs		1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69 4ZVZ 4ZX2 5HPE 5UI1 5WG8 7ZR5 7ZR6 8GAE 8GFT	2YRT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication D5 Dopamine Receptor Binding Neurofibrillary Tangle Assembly Protein Branched Polyubiquitination Circadian Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Binding MAP Kinase Kinase Kinase Activity Protein Localization To Organelle Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Metabolic Process Response To Metal Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphatase Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Main Axon Kinase Binding Regulation Of Gene Expression Regulation Of Proteolysis Rho-activating G Protein-coupled Receptor Signaling Pathway Hsp90 Protein Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Memory Regulation Of Cell Cycle Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Circadian Rhythm Protein Localization To Cytoskeleton Positive Regulation Of Cell Differentiation	Protein Folding Chaperone Complex Tau Protein Binding Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone Protein-containing Complex TPR Domain Binding Telomerase Holoenzyme Complex Assembly Melanosome Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase DNA Polymerase Binding Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Telomere Maintenance Via Telomere Lengthening Skeletal Muscle Contraction ATP-dependent Protein Folding Chaperone Positive Regulation Of Nitric Oxide Biosynthetic Process RNA Binding DNA Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Heat Protein Folding Chaperone Regulation Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Neuronal Cell Body Heat Shock Protein Binding Regulation Of Protein Catabolic Process CTP Binding DATP Binding Positive Regulation Of Protein Polymerization Striated Muscle Contraction Response To Unfolded Protein Response To Heat Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Alkaloid DNA Biosynthetic Process Telomere Maintenance Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding HSP90-CDC37 Chaperone Complex Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Cellular Response To Triglyceride Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Protein-containing Complex Assembly
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